Artificial Lymph Node Technology
When this technology was applied to monoclonal antibody production, the number of target monoclonal antibodies obtained per mouse became more than 10 times greater than that obtained by conventional methods. In addition, these monoclonal antibodies contained various ultra-high affinity clones. This means that diverse, high-quality monoclonal antibodies can be obtained at one time by using the artificial lymph node technology, as well as that this technology can possibly be used as an antibody production technology to create innovative monoclonal antibodies. Currently, we are engaging in improvements of the technology to produce more high-quality antibodies, while trying to develop new technologies for producing antibodies that are very difficult or impossible to obtain by the conventional methods.
1) Suematsu S and Watanabe T, Generation of synthetic lymphoid tissue-like organoid in mice. Nature Biotechnology. 22: 1539-1545, 2004 (PubMed: 15568019)