Immunogenicity-Enhancing Antigen Technology
The IEA (Immunogenicity-Enhancing Antigen) is our innovation in which genetic engineering of the target proteins (antigens) used for immunization is employed to enhance immunogenicity in mice. We used such modified antigens to successfully produce a dramatic increase in the mAb titer and the establishment of mAbs for proteins, which is difficult to accomplish by conventional methods. When combined with artificial lymph node technology, synergistic effects facilitate the isolation of a variety of mAbs. This technology has many applications and is particularly useful for the establishment of high-quality antibodies for any proteins.