Pathway Posters
Pathway Posters
Allergic Response PathwayPTPN6/SHP-1 plays a crucial role in negatively modulating insulin action and clearance in the liver, thereby regulating whole-body glucose homeostasis. PTPN6/SHP-1 has also reported a negative regulator in the development of allergic responses such as allergic asthma.
Pathway Posters
Alzheimer’s Disease PathwayAlzheimer’s disease is a type of dementia that causes problems with memory, thinking and behavior. It is the most common neurodegenerative disease affecting over 5 million people in the United States and there is currently no cure.
Pathway Posters
Autophagy PathwayAutophagy is a cellular self-digestion process for the purpose of providing nutrients to allow for cell survival during stress conditions. Autophagy can be selective (mitophagy) or non-selective (nutrient poor). Autophagy plays an important role in maintaining the cell homeostasis by removing non-essential cell components.
Pathway Posters
Cholesterol-Cardiovascular PathwayMBLI provides reagents for quantifying PCSK9, which is secretory protein binding to receptor of low-density lipoprotein (LDL) to increase blood levels of LDL cholesterol through suppressing the uptake of LDL cholesterol to liver cells.
Pathway Posters
Circadian Rhythm PathwayThe circadian clock is a 24-hour endogenous oscillator, which cycles via transcriptional/translational feedback loops of clock genes and their products in individual cells. CLOCK and BMAL1 are positive factors in the loop, and their complex binds to E-box elements of Period (PER) and Cryptochrome (CRY) genes.
Pathway Posters
Human Embryonic Stem Cell Pluripotency PathwayRecent studies with avian embryos and murine embryonic stem cells have suggested that hematopoietic cells are derived from hemangioblasts, the common precursors of hematopoietic and endothelial cells.
Pathway Posters
Immuno-Oncology PathwayThe study of T-cell regulation is important due to their crucial role in the immune response. T-cells have special surface receptors that differentiate healthy and abnormal cells. MHC tetramers are used to detect immune response to various diseases, including cancer. Tetramers are a powerful technology that allows for determination if a specific treatment is working. This information can potentially lead to vaccines or drug development.
Pathway Posters
miRNA/mRNA PathwayThe main classes of small ncRNA are short interfering RNAs (siRNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs). siRNAs are generated by cleavage of exogenous long double-stranded RNA precursors in response to viral infection or artificial introduction. In contrast, miRNAs are generated from endogenous transcripts containing stem-loop structures.
Pathway Posters
Mitophagy PathwayMitophagy detection vectors are designed for the co-expression of MT-mKeima-Red.
Pathway Posters
p53 in Cancer Pathwayp53 is an important factor in tumor suppression and is activated in response to cellular stress to induce cell cycle arrest or apoptosis. p53 mutants found in tumors are no longer functional as tumor suppressors, resulting in cell malignancies. The immune response in tumor patients correlates with the presence of p53 mutations, leading to the accumulation of ineffective p53 proteins in the tumor cells
Pathway Posters
S100 Family PathwayS100 protein family of calcium binding proteins with 2 distinct helix-loop-helix motifs (EF-hands) shows cell type-specific expression and consists of 20 members. The protein family functions by being secreted extracellularly as well as involved in intracellular signaling.
Pathway Posters
TCR Signaling PathwayZAP70 is a non-receptor protein tyrosine kinase (part of the Syk/Zap70 family) that is involved in signaling by the T-cell antigen receptor (TCR). Ligation of the TCR/CD3 receptor in Jurkat T-cells induces phosphoprotein complexes which contain ZAP70 (1).
Pathway Posters
Apoptosis PathwayApoptosis, a form of programmed cell death, is not only a major process within normal homeostasis but is present in disease states such as cancer and many autoimmune and neurodegenerative diseases.
