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White Papers

The Importance of Using an Isotype Control

Isotype controls are essential tools in a range of in vivo efficacy and immunoassays and are appropriate negative
controls for accurate measurement of antibody drug effects.

Blog

Why should you use Isotype Control Antibodies

Good experimental design is key to accurate and precise drug development. Isotype control antibodies, designed and deployed properly, optimize study performance and data analysis in therapeutic antibody research.

Blog

ELISA

Blog

PCSK9

Scientific Posters

A Reversible T Cell Exhaustion-Like In Vitro Assay to Screen Candidate Drugs

The information in this poster describes a T cell differentiation continuum of hierarchial progressive dimunition of effector function.

Blog

Exosomes

Blog

IL-18

Blog

Tetramers

Scientific Posters

HLA-A*02:01 QuickSwitch™ Quant Kit can be used for determining the biological activity of a cancer vaccine

The information in this poster describes our fast and user-friendly assay (QuickSwitch™ Quant) which can help both determine binding of novel peptides to MHC class I molecules and generate new specificity MHC class I tetramers for peptide specific T cell detection.

Pathway Posters

Allergic Response Pathway

PTPN6/SHP-1 plays a crucial role in negatively modulating insulin action and clearance in the liver, thereby regulating whole-body glucose homeostasis. PTPN6/SHP-1 has also reported a negative regulator in the development of allergic responses such as allergic asthma.

Pathway Posters

Alzheimer’s Disease Pathway

Alzheimer’s disease is a type of dementia that causes problems with memory, thinking and behavior. It is the most common neurodegenerative disease affecting over 5 million people in the United States and there is currently no cure.

Pathway Posters

Autophagy Pathway

Autophagy is a cellular self-digestion process for the purpose of providing nutrients to allow for cell survival during stress conditions. Autophagy can be selective (mitophagy) or non-selective (nutrient poor). Autophagy plays an important role in maintaining the cell homeostasis by removing non-essential cell components.

Pathway Posters

Cholesterol-Cardiovascular Pathway

MBLI provides reagents for quantifying PCSK9, which is secretory protein binding to receptor of low-density lipoprotein (LDL) to increase blood levels of LDL cholesterol through suppressing the uptake of LDL cholesterol to liver cells.

Pathway Posters

Circadian Rhythm Pathway

The circadian clock is a 24-hour endogenous oscillator, which cycles via transcriptional/translational feedback loops of clock genes and their products in individual cells. CLOCK and BMAL1 are positive factors in the loop, and their complex binds to E-box elements of Period (PER) and Cryptochrome (CRY) genes.

Pathway Posters

Human Embryonic Stem Cell Pluripotency Pathway

Recent studies with avian embryos and murine embryonic stem cells have suggested that hematopoietic cells are derived from hemangioblasts, the common precursors of hematopoietic and endothelial cells.

Pathway Posters

Immuno-Oncology Pathway

The study of T-cell regulation is important due to their crucial role in the immune response. T-cells have special surface receptors that differentiate healthy and abnormal cells. MHC tetramers are used to detect immune response to various diseases, including cancer. Tetramers are a powerful technology that allows for determination if a specific treatment is working. This information can potentially lead to vaccines or drug development.

Pathway Posters

miRNA/mRNA Pathway

The main classes of small ncRNA are short interfering RNAs (siRNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs). siRNAs are generated by cleavage of exogenous long double-stranded RNA precursors in response to viral infection or artificial introduction. In contrast, miRNAs are generated from endogenous transcripts containing stem-loop structures.

Pathway Posters

Mitophagy Pathway

Mitophagy detection vectors are designed for the co-expression of MT-mKeima-Red.

Pathway Posters

p53 in Cancer Pathway

p53 is an important factor in tumor suppression and is activated in response to cellular stress to induce cell cycle arrest or apoptosis. p53 mutants found in tumors are no longer functional as tumor suppressors, resulting in cell malignancies. The immune response in tumor patients correlates with the presence of p53 mutations, leading to the accumulation of ineffective p53 proteins in the tumor cells

Scientific Posters

RiboCluster Profiler™ Ribo Trap Kit: A novel tool to study regulatory components of mRNA of interest

Post-transcriptional regulation of gene expression plays important roles in most cellular processes such as development and metabolism as well as many diseases such as cancer.

Scientific Posters

RiboCluster Profiler™ RIP-Assay Kit for microRNA: A novel immunochemical tool to identify microRNA targets

MicroRNA's (miRNAs) are genomically encoded non-coding RNAs that take part in controlling gene expression. Mature miRNAs are integrated onto RNA-induced silencing complex (RISC) which targets messenger RNA (mRNA) to regulate their translation.

Pathway Posters

S100 Family Pathway

S100 protein family of calcium binding proteins with 2 distinct helix-loop-helix motifs (EF-hands) shows cell type-specific expression and consists of 20 members. The protein family functions by being secreted extracellularly as well as involved in intracellular signaling.

Pathway Posters

TCR Signaling Pathway

ZAP70 is a non-receptor protein tyrosine kinase (part of the Syk/Zap70 family) that is involved in signaling by the T-cell antigen receptor (TCR). Ligation of the TCR/CD3 receptor in Jurkat T-cells induces phosphoprotein complexes which contain ZAP70 (1).

Request our new Tetramer Staining Guide

MBL International's new Tetramer Staining Guide is a collection of protocols and data to help make your experiments a success.

Videos

Fluoppi: Visualizing Protein-Protein Interactions in Living Cells

Fluoppi is a novel technology that provides an easy way to visualize Protein-Protein interactions (PPIs) with a high signal to noise ratio.

Videos

Keima-Red Fluorescent Protein Vector for Mitophagy Monitoring in Living Cells

MBL International’s Keima-Red fluorescent vector provides a simple method for detecting mitophagy in living cells by using a unique excitation profile.

Blog

Mechanisms and detection methods of p62/SQSTM1 and its importance in the autophagy pathway.

The ubiquitin-conjugating protein p62/SQSTM1 is thought to be a scaffold protein that interacts with a variety of molecules involved in toll-like receptor (TLR) signaling, such as TRAF6, ERK, and aPKC. Recent evidence suggests that p62 binds directly to the autophagosome marker LC3 and is then selectively degraded by autophagy.

White Papers

Role of the autophagy regulator Rubicon in the pathogenesis of fatty liver disease.

In 2016, Dr. Tanaka, Dr. Yoshimori, and their colleagues clarified that increased expression of Rubicon in liver causes fatty liver. This was the first report to demonstrate fatty liver is caused by suppression of autophagy in an acquired environment. In this white paper, they describe details of correlation between Rubicon and fatty liver disease.

White Papers

White paper – Autophagy Research: Current Status and Future Perspectives

This white paper, authored by Dr. Noboru Mizushima of the University of Tokyo, describes the current state of autophagy research and future areas of research and drug discovery. He discusses the impact of the discovery of ATG genes in autophagy research, the role of autophagy in disease, and the development of therapeutics targeting the autophagy pathway.

Blog

LC3: The gold standard for autophagy research

LC3, a mammalian homologue of yeast ATG8, is a soluble protein that is distributed ubiquitously in mammalian tissues and cultured cells. LC3 has been studied most extensively and is frequently used as an autophagy marker in mammals. Newly translated LC3 (proLC3) is immediately processed at the C-terminus in order to form LC3-I. During autophagy, autophagosomes engulf cytoplasmic components, including cytosolic proteins and organelles. Concomitantly, a cytosolic form of LC3 (LC3-I) is conjugated to phosphatidylethanolamine to form LC3-phosphatidylethanolamine conjugate (LC3-II), which is recruited to autophagosomal membranes.

Blog

Give Your Research 100% With a S100 Antibody

S100 proteins are a family of proteins known for their role in a variety of cellular pathways and diseases. This blog post will catch you up on the latest research on these important proteins.

Pathway Posters

Apoptosis Pathway

Apoptosis, a form of programmed cell death, is not only a major process within normal homeostasis but is present in disease states such as cancer and many autoimmune and neurodegenerative diseases.

Blog

Is Wnt3a an essential component in organoid culture?

Organoids are self-organized three-dimensional tissue cultures that are derived from mammalian pluripotent or adult stem cells. These in-vitro-grown cell clusters are given possibilities to replicate much of the complexity of an organ. There are potentially as many types of organoids as there are different tissues and organs. To date, researchers have been able to prepare brain, kidney, lung, intestine, stomach, liver and many more are developing.

Application Notes

MHC Tetramer Staining with Human CD8 Clones

MHC Tetramer Staining with various human CD8 clones

Videos

MBL’s MHC Tetramers

The best method for monitoring T cells for antigen specificity. *Only Human and Macaque HLA Class I Tetramers contain the alpha 3 mutation.

Brochures

Immutex™ Latex Beads

Immutex™ is a uniform-sized polystyrene latex (PSL) particle for agglutination tests in clinical diagnostics.

Brochures

Magnosphere™ Magnetic Beads

Magnetic beads for life sciences research.

Videos

MHC Tetramers

An overview of MHC tetramers including Class I and Class II tetramers.. *Only Human and Macaque HLA Class I Tetramers contain the alpha 3 mutation.

Brochures

QuickSwitch™ HLA-A*11:01 tetramer kits

Quickly generate new high-quality tetramer specificities.

Application Notes

MHC Tetramer Guided Staining of peptide-specific CD8+ T cells in Peripheral Mononuclear Cells (PBMC) in a 96-well plate format

In this white paper we describe a method of tetramer staining and flow analysis in a 96-well plate format, for use with an automated plate handler.

Brochures

RIP-Assay Kit for miRNA

RIP-Assay Kit for miRNA

Brochures

Afamin/Wnt3a CM

Brochures

Allele List Flyer (Tetramers)

Allele List

Videos

Immunoprecipitation using SMART-IP

MBL International Corporation offers a line of highly specific antibodies conjugated to magnetic beads. This method is an advantage over conventional immunoprecipitation of tagged proteins because it eliminates time consuming centrifugation steps. The magnetic beads are covalently bound to a Tag antibody and the beads are easily isolated using a magnetic rack.

Brochures

ELISA Kits for Disease-related Biomarkers

ELISA Kits for Disease-related Biomarkers

Brochures

Autophagy-Related Products Catalog

Autophagy-Related Products Catalog

Brochures

p62 and phospho-p62 ELISA Kit, Autophagy

p62 and phospho-p62 ELISA Kit, Autophagy

Brochures

MHC Tetramers and Monomers for Immuno-Oncology and Autoimmunity Drug Discovery

MHC Tetramers and Monomers for Immun-Oncology and Autoimmunity Drug Discovery

Pathway Posters

Influenza A Pathway

Pathway Posters

Mitophagy Pathway

Brochures

Immuno-Oncology

The combination of oncology research and immunology research (Immuno-
Oncology) allows for a better understanding of how the immune system functions in relation to cancer.

Brochures

QuickSwitch™ Custom Tetramers Kits

QuickSwitch™ Custom Tetramer Kits

Brochures

ELISA Kits and Assays

ELISA Kits and Assays Flyer

Brochures

ExoCap™ Streptavidin Kit

ExoCap™ Streptavidin Flyer

Brochures

Flow Cytometry Reagents

Flow Cytometry Reagents Brochure

Brochures

Maxblot

MaxBlot is used as diluent for Western Blotting or ELISA.

Pathway Posters

Rho Family Pathway

Pathway Posters

Regulation of eIF4E

Pathway Posters

NF-KappaB Pathway

Pathway Posters

mTOR Pathway

Pathway Posters

MAPK Signaling

Pathway Posters

JNK Pathway

Pathway Posters

Histone Methylation Pathway

Pathway Posters

AMPK Pathway

Pathway Posters

Akt

Pathway Posters

14-3-3 Induced Apoptosis

Videos

Smart-IP: Tag antibodies conjugated to magnetic beads

MBL International Corporation offers a line of highly specific antibodies conjugated to magnetic beads.

Videos

MHC Tetramers and antigen-specific T cell receptors

Learn more about our patented MHC multimer technology. *Only Human and Macaque HLA Class I Tetramers contain the alpha 3 mutation.

Videos

RIP-Chip Assay for microRNA

Educational video for RIP-Chip assay technology for microRNA. Identify miRNAs bound to their mRNA targets.

Brochures

Tag Antibodies

Epitope tagging is a powerful and versatile method for detecting and purifying proteins expressed by cloned genes.

Brochures

Solute Carriers Antibodies

Solute carriers are membrane transport proteins that enable nutrients to pass into the cell through facilitated diffusion.

Brochures

Smart-IP Antibodies

Smart-IP is a line of highly specific tag antibodies conjugated to magnetic beads or magnetic agarose beads.

Brochures

RNA-Binding Protein Immunoprecipitation (RIP-Chip) Assay Kit

RIP-Chip is a technology used to identify functionally related mRNAs and other RNAs associated with RNA binding proteins (RBP).

Brochures

RiboTrap

Discover the RNA binding protein associated with your gene of interest

Brochures

RiboCluster Profiler Product Brochure

Novel Tools for Post-Transcriptional Regulation of Gene Expression Research

Brochures

Neuroscience

A comprehensive list of kits and antibodies for neuroscience research.

Brochures

MethylHunter

MethylHunter™ Kit enriches DNA fragments containing methylated CpG DNA by using recombinant His-tagged MBD1.

Brochures

Kinase Assay Kits

Kinase Detection and Inhibitor Screening Assay Kits

Brochures

Immunology Products

A comprehensive list of kits and antibodies for immunology research.

Brochures

FUCCI: Visualize Cell Cycle

Fucci is a set of fluorescent probes which enable the visualization of cell cycle progression in living cells.

Brochures

Fluoppi

Fluoppi detects protein-protein interactions as the absence of presence of fluorescent foci during inhibition or induction.

Brochures

Circadian Rhythm

BMAL1, CLOCK, PERs, and CRYs play central roles in the oscillation of the circadian rhythm.

Brochures

Cell Culture

The NanoCulture® Plate utilizes a nano-scale structure providing advantages over monolayer and 3D cell culture offerings.

Brochures

Exosome Isolation

ExoCap™ is a kit for exosome isolation and enrichment designed and optimized for use with cell culture supernatants.

Brochures

Cancer & Cell Proliferation

Antibodies and kits for cancer research.

Brochures

BRIC Kit

The BRIC Kit provides researchers with reproducible and accurate results for monitoring RNA half-life and stability in living cells.

Brochures

Autophagy Watch

The Autophagy Flux Assay kit contains multiple antibodies and inhibitors for the rapid and quantitative monitoring of autophagy flux.

Brochures

Autophagy

Highly specific antibodies to meet your needs in autophagy research

Brochures

Apoptosis

Apoptosis Signal Cascade and Detection Kits

Brochures

Anti-p53 ELISA Kit

ELISA test for the detection of tumor-associated autoantibodies (anti-p53 antibodies).

Brochures

AGE Related Kits

Advanced Glycation End-products (AGE) which play an important role in diabetes, atherosclerosis, aging, kidney disease and cancer.