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Technical Note-MHC-Peptide Exchange Technology ExplainedFinding the right peptide and MHC combination doesn’t need to be daunting! Discover quick and easy MHC-peptide exchange technologies and quantitate the peptide binding affinity.
Brochures
QR Codes-Research Areas and ProductsQR Codes to learn more about research areas and products.
Brochures
FGF-Max (Recombinant human FGF-1/FGF-2 chimera)Universal FGFR ligand as FGF-1 is a novel choice for organoid cultures
Inflammation is regulated by small glycoproteins called cytokines. Cytokines are cell signaling proteins in the immune response pathway1. Il-18 is a cytokine that primarily facilitates Th1-type immunoreactions by acting on T cells.
Application Notes
Application Note-MHC Tetramer Staining with Various Human CD8 ClonesWe compared the effects of 10 different anti-CD8 antibody clones with MBL’s MHC tetramer staining.
Application Notes
Application Note-Basic Tips For Tetramer StainingMHC Tetramer Guided Staining of peptide-specific CD8+ T cells in Peripheral Mononuclear Cells (PBMC) in a 96-well plate format, a practical note
Brochures
FluoppiFluoppi (Fluorescent based technology detecting Protein-Protein Interaction) is a novel technology used to detect PPI in living cells with a high signal to noise ratio.
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In Vivo Isotype Control AntibodiesCrownVivo™ isotype antibodies are the leading source for in vivo isotype controls among researchers in discovery, preclinical and clinical areas
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QuickSwitch™ Custom Tetramers Kits-Class II MHC TetramersFast, High-Quality Creation of New MHC Tetramer Specificities
Scientific Posters
Analysis of biomarkers in melanoma patients receiving ICI treatments: pre- vs post in responders and progressorsStudy of biomarkers of immune-related adverse events and responses in patients treated with immune checkpoint inhibitors may shed light into mechanisms of resistance, T cell exhaustion and other combinatorial therapies. The elevated levels of such biomarkers have potential to predict whether a treatment of PD-1 or PD-1/CTLA-4 antagonist combination will be effective in a certain melanoma patient. Therefore, it may potentially guide healthcare providers to change treatment plans.
Scientific Posters
QuickSwitchTM: a validated platform for both screening MHC binding SARS-CoV-2 peptides and making SARS-CoV-2 specific MHC class I and II tetramersThis scientific poster details how QuickSwitch is used to screen peptides for Class I and Class II for SARS-CoV-2.
White Papers
The Importance of Using an Isotype ControlIsotype controls are essential tools in a range of in vivo efficacy and immunoassays and are appropriate negative
controls for accurate measurement of antibody drug effects.
Blog
Why should you use Isotype Control AntibodiesGood experimental design is key to accurate and precise drug development. Isotype control antibodies, designed and deployed properly, optimize study performance and data analysis in therapeutic antibody research.
Scientific Posters
A Reversible T Cell Exhaustion-Like In Vitro Assay to Screen Candidate DrugsThe information in this poster describes a T cell differentiation continuum of hierarchial progressive dimunition of effector function.
Scientific Posters
HLA-A*02:01 QuickSwitch™ Quant Kit can be used for determining the biological activity of a cancer vaccineThe information in this poster describes our fast and user-friendly assay (QuickSwitch™ Quant) which can help both determine binding of novel peptides to MHC class I molecules and generate new specificity MHC class I tetramers for peptide specific T cell detection.
Pathway Posters
Allergic Response PathwayPTPN6/SHP-1 plays a crucial role in negatively modulating insulin action and clearance in the liver, thereby regulating whole-body glucose homeostasis. PTPN6/SHP-1 has also reported a negative regulator in the development of allergic responses such as allergic asthma.
Pathway Posters
Alzheimer’s Disease PathwayAlzheimer’s disease is a type of dementia that causes problems with memory, thinking and behavior. It is the most common neurodegenerative disease affecting over 5 million people in the United States and there is currently no cure.
Pathway Posters
Autophagy PathwayAutophagy is a cellular self-digestion process for the purpose of providing nutrients to allow for cell survival during stress conditions. Autophagy can be selective (mitophagy) or non-selective (nutrient poor). Autophagy plays an important role in maintaining the cell homeostasis by removing non-essential cell components.
Pathway Posters
Cholesterol-Cardiovascular PathwayMBLI provides reagents for quantifying PCSK9, which is secretory protein binding to receptor of low-density lipoprotein (LDL) to increase blood levels of LDL cholesterol through suppressing the uptake of LDL cholesterol to liver cells.
Pathway Posters
Circadian Rhythm PathwayThe circadian clock is a 24-hour endogenous oscillator, which cycles via transcriptional/translational feedback loops of clock genes and their products in individual cells. CLOCK and BMAL1 are positive factors in the loop, and their complex binds to E-box elements of Period (PER) and Cryptochrome (CRY) genes.
Pathway Posters
Human Embryonic Stem Cell Pluripotency PathwayRecent studies with avian embryos and murine embryonic stem cells have suggested that hematopoietic cells are derived from hemangioblasts, the common precursors of hematopoietic and endothelial cells.
Pathway Posters
Immuno-Oncology PathwayThe study of T-cell regulation is important due to their crucial role in the immune response. T-cells have special surface receptors that differentiate healthy and abnormal cells. MHC tetramers are used to detect immune response to various diseases, including cancer. Tetramers are a powerful technology that allows for determination if a specific treatment is working. This information can potentially lead to vaccines or drug development.
Pathway Posters
miRNA/mRNA PathwayThe main classes of small ncRNA are short interfering RNAs (siRNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs). siRNAs are generated by cleavage of exogenous long double-stranded RNA precursors in response to viral infection or artificial introduction. In contrast, miRNAs are generated from endogenous transcripts containing stem-loop structures.
Pathway Posters
Mitophagy PathwayMitophagy detection vectors are designed for the co-expression of MT-mKeima-Red.
Pathway Posters
p53 in Cancer Pathwayp53 is an important factor in tumor suppression and is activated in response to cellular stress to induce cell cycle arrest or apoptosis. p53 mutants found in tumors are no longer functional as tumor suppressors, resulting in cell malignancies. The immune response in tumor patients correlates with the presence of p53 mutations, leading to the accumulation of ineffective p53 proteins in the tumor cells
Scientific Posters
RiboCluster Profiler™ Ribo Trap Kit: A novel tool to study regulatory components of mRNA of interestPost-transcriptional regulation of gene expression plays important roles in most cellular processes such as development and metabolism as well as many diseases such as cancer.
Scientific Posters
RiboCluster Profiler™ RIP-Assay Kit for microRNA: A novel immunochemical tool to identify microRNA targetsMicroRNA's (miRNAs) are genomically encoded non-coding RNAs that take part in controlling gene expression. Mature miRNAs are integrated onto RNA-induced silencing complex (RISC) which targets messenger RNA (mRNA) to regulate their translation.
Pathway Posters
S100 Family PathwayS100 protein family of calcium binding proteins with 2 distinct helix-loop-helix motifs (EF-hands) shows cell type-specific expression and consists of 20 members. The protein family functions by being secreted extracellularly as well as involved in intracellular signaling.
Pathway Posters
TCR Signaling PathwayZAP70 is a non-receptor protein tyrosine kinase (part of the Syk/Zap70 family) that is involved in signaling by the T-cell antigen receptor (TCR). Ligation of the TCR/CD3 receptor in Jurkat T-cells induces phosphoprotein complexes which contain ZAP70 (1).
MBL International's new Tetramer Staining Guide is a collection of protocols and data to help make your experiments a success.
Videos
Fluoppi: Visualizing Protein-Protein Interactions in Living CellsFluoppi is a novel technology that provides an easy way to visualize Protein-Protein interactions (PPIs) with a high signal to noise ratio.
Videos
Keima-Red Fluorescent Protein Vector for Mitophagy Monitoring in Living CellsMBL International’s Keima-Red fluorescent vector provides a simple method for detecting mitophagy in living cells by using a unique excitation profile.
Blog
Mechanisms and detection methods of p62/SQSTM1 and its importance in the autophagy pathway.The ubiquitin-conjugating protein p62/SQSTM1 is thought to be a scaffold protein that interacts with a variety of molecules involved in toll-like receptor (TLR) signaling, such as TRAF6, ERK, and aPKC. Recent evidence suggests that p62 binds directly to the autophagosome marker LC3 and is then selectively degraded by autophagy.
White Papers
Role of the autophagy regulator Rubicon in the pathogenesis of fatty liver disease.In 2016, Dr. Tanaka, Dr. Yoshimori, and their colleagues clarified that increased expression of Rubicon in liver causes fatty liver. This was the first report to demonstrate fatty liver is caused by suppression of autophagy in an acquired environment. In this white paper, they describe details of correlation between Rubicon and fatty liver disease.
White Papers
White paper – Autophagy Research: Current Status and Future PerspectivesThis white paper, authored by Dr. Noboru Mizushima of the University of Tokyo, describes the current state of autophagy research and future areas of research and drug discovery. He discusses the impact of the discovery of ATG genes in autophagy research, the role of autophagy in disease, and the development of therapeutics targeting the autophagy pathway.
Blog
LC3: The gold standard for autophagy researchLC3, a mammalian homologue of yeast ATG8, is a soluble protein that is distributed ubiquitously in mammalian tissues and cultured cells. LC3 has been studied most extensively and is frequently used as an autophagy marker in mammals. Newly translated LC3 (proLC3) is immediately processed at the C-terminus in order to form LC3-I. During autophagy, autophagosomes engulf cytoplasmic components, including cytosolic proteins and organelles. Concomitantly, a cytosolic form of LC3 (LC3-I) is conjugated to phosphatidylethanolamine to form LC3-phosphatidylethanolamine conjugate (LC3-II), which is recruited to autophagosomal membranes.
Blog
Give Your Research 100% With a S100 AntibodyS100 proteins are a family of proteins known for their role in a variety of cellular pathways and diseases. This blog post will catch you up on the latest research on these important proteins.
Pathway Posters
Apoptosis PathwayApoptosis, a form of programmed cell death, is not only a major process within normal homeostasis but is present in disease states such as cancer and many autoimmune and neurodegenerative diseases.
Blog
Is Wnt3a an essential component in organoid culture?Organoids are self-organized three-dimensional tissue cultures that are derived from mammalian pluripotent or adult stem cells. These in-vitro-grown cell clusters are given possibilities to replicate much of the complexity of an organ. There are potentially as many types of organoids as there are different tissues and organs. To date, researchers have been able to prepare brain, kidney, lung, intestine, stomach, liver and many more are developing.
Videos
MBL’s MHC TetramersThe best method for monitoring T cells for antigen specificity. *Only Human and Macaque HLA Class I Tetramers contain the alpha 3 mutation.
Brochures
Immutex™ Latex BeadsImmutex™ is a uniform-sized polystyrene latex (PSL) particle for agglutination tests in clinical diagnostics.
Videos
MHC TetramersAn overview of MHC tetramers including Class I and Class II tetramers.. *Only Human and Macaque HLA Class I Tetramers contain the alpha 3 mutation.
Brochures
Afamin/Wnt3a Condition Medium-Organoid Cell CultureBy using Afamin and Wnt3a complex for organoid culture, long term culture of organoid becomes possible. This new medium will result in optimal success for your organoid experiments.
Brochures
Class II TetramersStay up to date with Class II tetramer offerings from MBLI. Detect CD4+ T Cell with ease and reliability
Videos
Immunoprecipitation using SMART-IPMBL International Corporation offers a line of highly specific antibodies conjugated to magnetic beads. This method is an advantage over conventional immunoprecipitation of tagged proteins because it eliminates time consuming centrifugation steps. The magnetic beads are covalently bound to a Tag antibody and the beads are easily isolated using a magnetic rack.
Brochures
MHC Tetramers and Monomers for Immuno-Oncology and Autoimmunity Drug DiscoveryMHC Tetramers and Monomers for Immun-Oncology and Autoimmunity Drug Discovery
Brochures
Immuno-OncologyThe combination of oncology research and immunology research (Immuno-
Oncology) allows for a better understanding of how the immune system functions in relation to cancer.
Brochures
QuickSwitch™ Custom Tetramers Kits-Class I MHC TetramersFast, High-Quality Creation of New MHC Tetramer Specificities
Videos
Smart-IP: Tag antibodies conjugated to magnetic beadsMBL International Corporation offers a line of highly specific antibodies conjugated to magnetic beads.
Videos
MHC Tetramers and antigen-specific T cell receptorsLearn more about our patented MHC multimer technology. *Only Human and Macaque HLA Class I Tetramers contain the alpha 3 mutation.
Videos
RIP-Chip Assay for microRNAEducational video for RIP-Chip assay technology for microRNA. Identify miRNAs bound to their mRNA targets.
Brochures
Tag AntibodiesEpitope tagging is a powerful and versatile method for detecting and purifying proteins expressed by cloned genes.
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RNA-Binding Protein Immunoprecipitation (RIP-Chip) Assay KitRIP-Chip is a technology used to identify functionally related mRNAs and other RNAs associated with RNA binding proteins (RBP).
Brochures
FUCCI (Fluorescence Ubiquitination-based Cell Cycle Indicator)Fucci is a set of fluorescent probes which enable the visualization of cell cycle progression in living cells.
