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Inflammation is regulated by small glycoproteins called cytokines. Cytokines are cell signaling proteins in the immune response pathway1. Il-18 is a cytokine that primarily facilitates Th1-type immunoreactions by acting on T cells.
Application NotesApplication Note-MHC Tetramer Staining with Various Human CD8 Clones
We compared the effects of 10 different anti-CD8 antibody clones with MBL’s MHC tetramer staining.
Application NotesApplication Note-Basic Tips For Tetramer Staining
MHC Tetramer Guided Staining of peptide-specific CD8+ T cells in Peripheral Mononuclear Cells (PBMC) in a 96-well plate format, a practical note
Fluoppi (Fluorescent based technology detecting Protein-Protein Interaction) is a novel technology used to detect PPI in living cells with a high signal to noise ratio.
BrochuresIn Vivo Isotype Control Antibodies
CrownVivo™ isotype antibodies are the leading source for in vivo isotype controls among researchers in discovery, preclinical and clinical areas
BrochuresCMV Specific Tetramers
BrochuresQuickSwitch™ Custom Tetramers Kits-Class II MHC Tetramers
Fast, High-Quality Creation of New MHC Tetramer Specificities
BrochuresSARS-Cov-2 MHC-Peptide Screening Kit Bundles Flyer
QuickSwitch™ Tetramer kits and Peptides
Scientific PostersAnalysis of biomarkers in melanoma patients receiving ICI treatments: pre- vs post in responders and progressors
Study of biomarkers of immune-related adverse events and responses in patients treated with immune checkpoint inhibitors may shed light into mechanisms of resistance, T cell exhaustion and other combinatorial therapies. The elevated levels of such biomarkers have potential to predict whether a treatment of PD-1 or PD-1/CTLA-4 antagonist combination will be effective in a certain melanoma patient. Therefore, it may potentially guide healthcare providers to change treatment plans.
Scientific PostersQuickSwitchTM: a validated platform for both screening MHC binding SARS-CoV-2 peptides and making SARS-CoV-2 specific MHC class I and II tetramers
This scientific poster details how QuickSwitch is used to screen peptides for Class I and Class II for SARS-CoV-2.
BrochuresT-Select Human MR1 Tetramer
White PapersThe Importance of Using an Isotype Control
Isotype controls are essential tools in a range of in vivo efficacy and immunoassays and are appropriate negative
controls for accurate measurement of antibody drug effects.
BlogWhy should you use Isotype Control Antibodies
Good experimental design is key to accurate and precise drug development. Isotype control antibodies, designed and deployed properly, optimize study performance and data analysis in therapeutic antibody research.
BrochuresQuickSwitch™ Peptide Screening Kit
BlogAutophagy – Blog
White PapersARS Antibodies Myositis Biomarkers
BrochuresEpitope Tag- Tag Antibodies and Kits
Scientific PostersA Reversible T Cell Exhaustion-Like In Vitro Assay to Screen Candidate Drugs
The information in this poster describes a T cell differentiation continuum of hierarchial progressive dimunition of effector function.
Blog3d Cell Culture
Scientific PostersHLA-A*02:01 QuickSwitch™ Quant Kit can be used for determining the biological activity of a cancer vaccine
The information in this poster describes our fast and user-friendly assay (QuickSwitch™ Quant) which can help both determine binding of novel peptides to MHC class I molecules and generate new specificity MHC class I tetramers for peptide specific T cell detection.
Pathway PostersAllergic Response Pathway
PTPN6/SHP-1 plays a crucial role in negatively modulating insulin action and clearance in the liver, thereby regulating whole-body glucose homeostasis. PTPN6/SHP-1 has also reported a negative regulator in the development of allergic responses such as allergic asthma.
Pathway PostersAlzheimer’s Disease Pathway
Alzheimer’s disease is a type of dementia that causes problems with memory, thinking and behavior. It is the most common neurodegenerative disease affecting over 5 million people in the United States and there is currently no cure.
Pathway PostersAutophagy Pathway
Autophagy is a cellular self-digestion process for the purpose of providing nutrients to allow for cell survival during stress conditions. Autophagy can be selective (mitophagy) or non-selective (nutrient poor). Autophagy plays an important role in maintaining the cell homeostasis by removing non-essential cell components.
Pathway PostersCholesterol-Cardiovascular Pathway
MBLI provides reagents for quantifying PCSK9, which is secretory protein binding to receptor of low-density lipoprotein (LDL) to increase blood levels of LDL cholesterol through suppressing the uptake of LDL cholesterol to liver cells.
Pathway PostersCircadian Rhythm Pathway
The circadian clock is a 24-hour endogenous oscillator, which cycles via transcriptional/translational feedback loops of clock genes and their products in individual cells. CLOCK and BMAL1 are positive factors in the loop, and their complex binds to E-box elements of Period (PER) and Cryptochrome (CRY) genes.
Pathway PostersHuman Embryonic Stem Cell Pluripotency Pathway
Recent studies with avian embryos and murine embryonic stem cells have suggested that hematopoietic cells are derived from hemangioblasts, the common precursors of hematopoietic and endothelial cells.
Pathway PostersImmuno-Oncology Pathway
The study of T-cell regulation is important due to their crucial role in the immune response. T-cells have special surface receptors that differentiate healthy and abnormal cells. MHC tetramers are used to detect immune response to various diseases, including cancer. Tetramers are a powerful technology that allows for determination if a specific treatment is working. This information can potentially lead to vaccines or drug development.
Pathway PostersmiRNA/mRNA Pathway
The main classes of small ncRNA are short interfering RNAs (siRNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs). siRNAs are generated by cleavage of exogenous long double-stranded RNA precursors in response to viral infection or artificial introduction. In contrast, miRNAs are generated from endogenous transcripts containing stem-loop structures.
Pathway PostersMitophagy Pathway
Mitophagy detection vectors are designed for the co-expression of MT-mKeima-Red.
Pathway Postersp53 in Cancer Pathway
p53 is an important factor in tumor suppression and is activated in response to cellular stress to induce cell cycle arrest or apoptosis. p53 mutants found in tumors are no longer functional as tumor suppressors, resulting in cell malignancies. The immune response in tumor patients correlates with the presence of p53 mutations, leading to the accumulation of ineffective p53 proteins in the tumor cells
Scientific PostersRiboCluster Profiler™ Ribo Trap Kit: A novel tool to study regulatory components of mRNA of interest
Post-transcriptional regulation of gene expression plays important roles in most cellular processes such as development and metabolism as well as many diseases such as cancer.
Scientific PostersRiboCluster Profiler™ RIP-Assay Kit for microRNA: A novel immunochemical tool to identify microRNA targets
MicroRNA's (miRNAs) are genomically encoded non-coding RNAs that take part in controlling gene expression. Mature miRNAs are integrated onto RNA-induced silencing complex (RISC) which targets messenger RNA (mRNA) to regulate their translation.
Pathway PostersS100 Family Pathway
S100 protein family of calcium binding proteins with 2 distinct helix-loop-helix motifs (EF-hands) shows cell type-specific expression and consists of 20 members. The protein family functions by being secreted extracellularly as well as involved in intracellular signaling.
Pathway PostersTCR Signaling Pathway
ZAP70 is a non-receptor protein tyrosine kinase (part of the Syk/Zap70 family) that is involved in signaling by the T-cell antigen receptor (TCR). Ligation of the TCR/CD3 receptor in Jurkat T-cells induces phosphoprotein complexes which contain ZAP70 (1).
MBL International's new Tetramer Staining Guide is a collection of protocols and data to help make your experiments a success.
VideosFluoppi: Visualizing Protein-Protein Interactions in Living Cells
Fluoppi is a novel technology that provides an easy way to visualize Protein-Protein interactions (PPIs) with a high signal to noise ratio.
VideosKeima-Red Fluorescent Protein Vector for Mitophagy Monitoring in Living Cells
MBL International’s Keima-Red fluorescent vector provides a simple method for detecting mitophagy in living cells by using a unique excitation profile.
BlogMechanisms and detection methods of p62/SQSTM1 and its importance in the autophagy pathway.
The ubiquitin-conjugating protein p62/SQSTM1 is thought to be a scaffold protein that interacts with a variety of molecules involved in toll-like receptor (TLR) signaling, such as TRAF6, ERK, and aPKC. Recent evidence suggests that p62 binds directly to the autophagosome marker LC3 and is then selectively degraded by autophagy.
White PapersRole of the autophagy regulator Rubicon in the pathogenesis of fatty liver disease.
In 2016, Dr. Tanaka, Dr. Yoshimori, and their colleagues clarified that increased expression of Rubicon in liver causes fatty liver. This was the first report to demonstrate fatty liver is caused by suppression of autophagy in an acquired environment. In this white paper, they describe details of correlation between Rubicon and fatty liver disease.
White PapersWhite paper – Autophagy Research: Current Status and Future Perspectives
This white paper, authored by Dr. Noboru Mizushima of the University of Tokyo, describes the current state of autophagy research and future areas of research and drug discovery. He discusses the impact of the discovery of ATG genes in autophagy research, the role of autophagy in disease, and the development of therapeutics targeting the autophagy pathway.
BlogLC3: The gold standard for autophagy research
LC3, a mammalian homologue of yeast ATG8, is a soluble protein that is distributed ubiquitously in mammalian tissues and cultured cells. LC3 has been studied most extensively and is frequently used as an autophagy marker in mammals. Newly translated LC3 (proLC3) is immediately processed at the C-terminus in order to form LC3-I. During autophagy, autophagosomes engulf cytoplasmic components, including cytosolic proteins and organelles. Concomitantly, a cytosolic form of LC3 (LC3-I) is conjugated to phosphatidylethanolamine to form LC3-phosphatidylethanolamine conjugate (LC3-II), which is recruited to autophagosomal membranes.
BlogGive Your Research 100% With a S100 Antibody
S100 proteins are a family of proteins known for their role in a variety of cellular pathways and diseases. This blog post will catch you up on the latest research on these important proteins.
Pathway PostersApoptosis Pathway
Apoptosis, a form of programmed cell death, is not only a major process within normal homeostasis but is present in disease states such as cancer and many autoimmune and neurodegenerative diseases.
BlogIs Wnt3a an essential component in organoid culture?
Organoids are self-organized three-dimensional tissue cultures that are derived from mammalian pluripotent or adult stem cells. These in-vitro-grown cell clusters are given possibilities to replicate much of the complexity of an organ. There are potentially as many types of organoids as there are different tissues and organs. To date, researchers have been able to prepare brain, kidney, lung, intestine, stomach, liver and many more are developing.
VideosMBL’s MHC Tetramers
The best method for monitoring T cells for antigen specificity. *Only Human and Macaque HLA Class I Tetramers contain the alpha 3 mutation.
BrochuresImmutex™ Latex Beads
Immutex™ is a uniform-sized polystyrene latex (PSL) particle for agglutination tests in clinical diagnostics.
BrochuresMagnosphere™ Magnetic Beads
Magnetic beads for life sciences research.
An overview of MHC tetramers including Class I and Class II tetramers.. *Only Human and Macaque HLA Class I Tetramers contain the alpha 3 mutation.
BrochuresRIP-Assay Kit for miRNA
RIP-Assay Kit for miRNA
BrochuresA Reversible T cell exhaustion model
BrochuresAfamin/Wnt3a Condition Medium-Organoid Cell Culture
By using Afamin and Wnt3a complex for organoid culture, long term culture of organoid becomes possible. This new medium will result in optimal success for your organoid experiments.
BrochuresClass II Tetramers
Stay up to date with Class II tetramer offerings from MBLI. Detect CD4+ T Cell with ease and reliability
BrochuresAllele List Flyer (Tetramers)
VideosImmunoprecipitation using SMART-IP
MBL International Corporation offers a line of highly specific antibodies conjugated to magnetic beads. This method is an advantage over conventional immunoprecipitation of tagged proteins because it eliminates time consuming centrifugation steps. The magnetic beads are covalently bound to a Tag antibody and the beads are easily isolated using a magnetic rack.
BrochuresELISA Kits for Disease-related Biomarkers
ELISA Kits for Disease-related Biomarkers
BrochuresAutophagy-Related Products Catalog
Autophagy-Related Products Catalog
Brochuresp62 and phospho-p62 ELISA Kit, Autophagy
p62 and phospho-p62 ELISA Kit, Autophagy
BrochuresMHC Tetramers and Monomers for Immuno-Oncology and Autoimmunity Drug Discovery
MHC Tetramers and Monomers for Immun-Oncology and Autoimmunity Drug Discovery
Pathway PostersHSV Pathway (Tetramers Target)
Pathway PostersInfluenza A Pathway
Scientific PostersEstablishment of a Cell Line Visualizing cMyc-Max Interaction
The combination of oncology research and immunology research (Immuno-
Oncology) allows for a better understanding of how the immune system functions in relation to cancer.
BrochuresQuickSwitch™ Custom Tetramers Kits-Class I MHC Tetramers
Fast, High-Quality Creation of New MHC Tetramer Specificities
BrochuresBiomarker ELISA and Assay Kits
BrochuresExoCap™ Streptavidin Kit
ExoCap™ Streptavidin Flyer
BrochuresFlow Cytometry Reagents
Flow Cytometry Reagents Brochure
BrochuresMitophagy Monitoring In Living Cells
Scientific PostersMetal-Conjugated NeutrAvidin for MHC Multimer Assays Using Mass Cytometry
Pathway PostersRho Family Pathway
Pathway PostersRegulation of eIF4E
Pathway PostersParkinson’s Disease Pathway
Pathway PostersNF-KappaB Pathway
Pathway PostersmTOR Pathway
Pathway PostersMAPK Signaling
Pathway PostersJNK Pathway
Pathway PostersHistone Methylation Pathway
Pathway PostersAMPK Pathway
Pathway Posters14-3-3 Induced Apoptosis
VideosSmart-IP: Tag antibodies conjugated to magnetic beads
MBL International Corporation offers a line of highly specific antibodies conjugated to magnetic beads.
VideosMHC Tetramers and antigen-specific T cell receptors
Learn more about our patented MHC multimer technology. *Only Human and Macaque HLA Class I Tetramers contain the alpha 3 mutation.
VideosRIP-Chip Assay for microRNA
Educational video for RIP-Chip assay technology for microRNA. Identify miRNAs bound to their mRNA targets.
Epitope tagging is a powerful and versatile method for detecting and purifying proteins expressed by cloned genes.
BrochuresRNA-Binding Protein Immunoprecipitation (RIP-Chip) Assay Kit
RIP-Chip is a technology used to identify functionally related mRNAs and other RNAs associated with RNA binding proteins (RBP).
A comprehensive list of kits and antibodies for neuroscience research.
BrochuresKinase Assay Kits
Kinase Detection and Inhibitor Screening Assay Kits
BrochuresFUCCI (Fluorescence Ubiquitination-based Cell Cycle Indicator)
Fucci is a set of fluorescent probes which enable the visualization of cell cycle progression in living cells.
Highly specific antibodies to meet your needs in autophagy research