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Blog: Crucial Niche Factors for Organoid CulturesCulturing organoids or stem cells in vitro is difficult. Afamin/Wnt3a and FGF-Max are 2 components found by many researchers to dramatically improve their cultures. Read more for details.
Webinars
Webinar: Simulating COVID-19 peptide presentation using the QuickSwitch™ MHC PlatformIn this presentation Dr. Yuri Poluektov focuses on the QuickSwitch™ MHC Platform, how it works and what the advantages are over regular tetramers.
Webinars
Webinar: Recall antigen assay to test the efficacy of checkpoint blockade therapeuticsDr. Orkash Hushur, Business Development Manager/Study Director, presents: Recall antigen assay to test the efficacy of checkpoint blockade therapeutics.
Webinars
Webinar: The importance of in vivo isotype control selection in antibody-based studiesDr. Beata Boczkowska, Product Manager, focuses on best practices for the use of isotype controls for in vivo studies in animals. Learn how to set up pre-clinical experiments that will easily transition to downstream clinical experiments easily.
Webinars
Webinar: Improve your organoid cultures with Wnt3a and FGF-MaxKazuya Arai presents an informative webinar focusing onWnt3a and FGF and how they can play a critical role for Adult Stem Cell-Derived Organoids
Brochures
Brochure: Anti-lntegrin αvβ6 ELISA KitAnti-lntegrin αvβ6 ELISA Kit is a kit to provide a highly specific detection of anti-integrin αvβ6 autoantibody in human serum.
Scientific Posters
Scientific Poster: Optimal Wnt Agonist for High LGR5+ Intestinal Organoid Growth and Functional Differenciated Organoid InductionWnt has been widely used as an essential factor in human intestinal organoids. Although recombinant Wnt3a is commonly utilized as Wnt source in organoid culture, a single Wnt3a protein is water insoluble and is not stable in culture medium. Recently, recombinant Afamin/Wnt3a and Wnt Surrogate-Fe Fusion Protein were developed. These Wnt agonists are stable as a medium supplement and support long-term organoid proliferation.
Application Notes
Technical Note: MHC-Peptide Exchange Technology ExplainedFinding the right peptide and MHC combination doesn’t need to be daunting! Discover quick and easy MHC-peptide exchange technologies and quantitate the peptide binding affinity.
Brochures
Brochure: QR Codes-Research Areas and ProductsQR Codes to learn more about research areas and products.
Brochures
Brochure: FGF-Max (Recombinant human FGF-1/FGF-2 chimera)Universal FGFR ligand as FGF-1 is a novel choice for organoid cultures
Blog
Blog: The Significance of IL-18 in the Inflammatory ResponseInflammation is regulated by small glycoproteins called cytokines. Cytokines are cell signaling proteins in the immune response pathway1. Il-18 is a cytokine that primarily facilitates Th1-type immunoreactions by acting on T cells.
Application Notes
Application Note: MHC Tetramer Staining with Various Human CD8 ClonesWe compared the effects of 10 different anti-CD8 antibody clones with MBL’s MHC tetramer staining.
Application Notes
Application Note: Basic Tips For Tetramer StainingMHC Tetramer Guided Staining of peptide-specific CD8+ T cells in Peripheral Mononuclear Cells (PBMC) in a 96-well plate format, a practical note
Brochures
Brochure: FluoppiFluoppi (Fluorescent based technology detecting Protein-Protein Interaction) is a novel technology used to detect PPI in living cells with a high signal to noise ratio.
Brochures
Brochure: In Vivo Isotype Control AntibodiesCrownVivo™ isotype antibodies are the leading source for in vivo isotype controls among researchers in discovery, preclinical and clinical areas
Brochures
Brochure: QuickSwitch™ Custom Tetramers Kits-Class II MHC TetramersFast, High-Quality Creation of New MHC Tetramer Specificities
Brochures
Brochure: SARS-Cov-2 MHC-Peptide Screening Kit Bundles FlyerQuickSwitch™ Tetramer kits and Peptides
Scientific Posters
Scientific Poster: Analysis of biomarkers in melanoma patients receiving ICI treatments: pre- vs post in responders and progressorsStudy of biomarkers of immune-related adverse events and responses in patients treated with immune checkpoint inhibitors may shed light into mechanisms of resistance, T cell exhaustion and other combinatorial therapies. The elevated levels of such biomarkers have potential to predict whether a treatment of PD-1 or PD-1/CTLA-4 antagonist combination will be effective in a certain melanoma patient. Therefore, it may potentially guide healthcare providers to change treatment plans.
Scientific Posters
Scientific Poster: QuickSwitch™: a validated platform for both screening MHC binding SARS-CoV-2 peptides and making SARS-CoV-2 specific MHC class I and II tetramersThis scientific poster details how QuickSwitch™ is used to screen peptides for Class I and Class II for SARS-CoV-2.
Webinars
Webinar: Practical use of endoderm derived organoids generated from non-human primatesIn this presentation Professor Ken Iwatsuki of Tokyo University of Agriculture focuses on organoids and organoids culture. In addition he presents choices of Wnt3a sources and research examples using organoids from monkeys as well as a discussion with the audience.
White Papers
White Paper: The Importance of Using an Isotype ControlIsotype controls are essential tools in a range of in vivo efficacy and immunoassays and are appropriate negative controls for accurate measurement of antibody drug effects.
Blog
Blog: Why should you use Isotype Control AntibodiesGood experimental design is key to accurate and precise drug development. Isotype control antibodies, designed and deployed properly, optimize study performance and data analysis in therapeutic antibody research.
Webinars
Webinar: Best Practices for Antigen Specific T Cell Detection by using MHC TetramersIn this presentation we focus on using MHC tetramers for cell surface staining to detect antigen specific T cell populations. We will also cover many interesting topics including, sample preparation for cell staining, gating strategies for Flow Cytometry and techniques to ensure reduced background and high signal.
Webinars
Webinar: T Cell Dysfunction Assays; Functional characterization of immunomodulatory candidate drugsIn this presentation you will learn about T cell dysfunction assays developed using our tetramer technology and more.
Scientific Posters
Scientific Poster: A Reversible T Cell Exhaustion-Like In Vitro Assay to Screen Candidate DrugsThe information in this poster describes a T cell differentiation continuum of hierarchial progressive dimunition of effector function.
Scientific Posters
Scientific Poster: HLA-A*02:01 QuickSwitch™ Quant Kit can be used for determining the biological activity of a cancer vaccineThe information in this poster describes our fast and user-friendly assay (QuickSwitch™ Quant) which can help both determine binding of novel peptides to MHC class I molecules and generate new specificity MHC class I tetramers for peptide specific T cell detection.
Pathway Posters
Pathway Poster: Allergic ResponsePTPN6/SHP-1 plays a crucial role in negatively modulating insulin action and clearance in the liver, thereby regulating whole-body glucose homeostasis. PTPN6/SHP-1 has also reported a negative regulator in the development of allergic responses such as allergic asthma.
Pathway Posters
Pathway Poster: Alzheimer’s DiseaseAlzheimer’s disease is a type of dementia that causes problems with memory, thinking and behavior. It is the most common neurodegenerative disease affecting over 5 million people in the United States and there is currently no cure.
Pathway Posters
Pathway Poster: AutophagyAutophagy is a cellular self-digestion process for the purpose of providing nutrients to allow for cell survival during stress conditions. Autophagy can be selective (mitophagy) or non-selective (nutrient poor). Autophagy plays an important role in maintaining the cell homeostasis by removing non-essential cell components.
Pathway Posters
Pathway Poster: Cholesterol-CardiovascularMBLI provides reagents for quantifying PCSK9, which is secretory protein binding to receptor of low-density lipoprotein (LDL) to increase blood levels of LDL cholesterol through suppressing the uptake of LDL cholesterol to liver cells.
Pathway Posters
Pathway Poster: Circadian RhythmThe circadian clock is a 24-hour endogenous oscillator, which cycles via transcriptional/translational feedback loops of clock genes and their products in individual cells. CLOCK and BMAL1 are positive factors in the loop, and their complex binds to E-box elements of Period (PER) and Cryptochrome (CRY) genes.
Pathway Posters
Pathway Poster: Human Embryonic Stem Cell PluripotencyRecent studies with avian embryos and murine embryonic stem cells have suggested that hematopoietic cells are derived from hemangioblasts, the common precursors of hematopoietic and endothelial cells.
Pathway Posters
Pathway Poster: Immuno-OncologyThe study of T-cell regulation is important due to their crucial role in the immune response. T-cells have special surface receptors that differentiate healthy and abnormal cells. MHC tetramers are used to detect immune response to various diseases, including cancer. Tetramers are a powerful technology that allows for determination if a specific treatment is working. This information can potentially lead to vaccines or drug development.
Pathway Posters
Pathwway Poster: miRNA/mRNAThe main classes of small ncRNA are short interfering RNAs (siRNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs). siRNAs are generated by cleavage of exogenous long double-stranded RNA precursors in response to viral infection or artificial introduction. In contrast, miRNAs are generated from endogenous transcripts containing stem-loop structures.
Pathway Posters
Pathway Poster: MitophagyMitophagy detection vectors are designed for the co-expression of MT-mKeima-Red.
Pathway Posters
Pathway Poster: p53 in Cancerp53 is an important factor in tumor suppression and is activated in response to cellular stress to induce cell cycle arrest or apoptosis. p53 mutants found in tumors are no longer functional as tumor suppressors, resulting in cell malignancies. The immune response in tumor patients correlates with the presence of p53 mutations, leading to the accumulation of ineffective p53 proteins in the tumor cells
Scientific Posters
Scientific Poster: RiboCluster Profiler™ Ribo Trap Kit: A novel tool to study regulatory components of mRNA of interestPost-transcriptional regulation of gene expression plays important roles in most cellular processes such as development and metabolism as well as many diseases such as cancer.
Scientific Posters
Scientific Poster: RiboCluster Profiler™ RIP-Assay Kit for microRNA: A novel immunochemical tool to identify microRNA targetsMicroRNA's (miRNAs) are genomically encoded non-coding RNAs that take part in controlling gene expression. Mature miRNAs are integrated onto RNA-induced silencing complex (RISC) which targets messenger RNA (mRNA) to regulate their translation.
Pathway Posters
Pathway Poster: S100 FamilyS100 protein family of calcium binding proteins with 2 distinct helix-loop-helix motifs (EF-hands) shows cell type-specific expression and consists of 20 members. The protein family functions by being secreted extracellularly as well as involved in intracellular signaling.
Pathway Posters
Pathway Poster: TCR SignalingZAP70 is a non-receptor protein tyrosine kinase (part of the Syk/Zap70 family) that is involved in signaling by the T-cell antigen receptor (TCR). Ligation of the TCR/CD3 receptor in Jurkat T-cells induces phosphoprotein complexes which contain ZAP70 (1).
Brochures
Brochure: Tetramer Staining GuideMBL International's new Tetramer Staining Guide is a collection of protocols and data to help make your experiments a success.
Videos
Video: Fluoppi: Visualizing Protein-Protein Interactions in Living CellsFluoppi is a novel technology that provides an easy way to visualize Protein-Protein interactions (PPIs) with a high signal to noise ratio.
Videos
Video: Keima-Red Fluorescent Protein Vector for Mitophagy Monitoring in Living CellsMBL International’s Keima-Red fluorescent vector provides a simple method for detecting mitophagy in living cells by using a unique excitation profile.
Blog
Blog: Mechanisms and detection methods of p62/SQSTM1 and its importance in the autophagy pathway.The ubiquitin-conjugating protein p62/SQSTM1 is thought to be a scaffold protein that interacts with a variety of molecules involved in toll-like receptor (TLR) signaling, such as TRAF6, ERK, and aPKC. Recent evidence suggests that p62 binds directly to the autophagosome marker LC3 and is then selectively degraded by autophagy.
White Papers
White Paper: Role of the autophagy regulator Rubicon in the pathogenesis of fatty liver disease.In 2016, Dr. Tanaka, Dr. Yoshimori, and their colleagues clarified that increased expression of Rubicon in liver causes fatty liver. This was the first report to demonstrate fatty liver is caused by suppression of autophagy in an acquired environment. In this white paper, they describe details of correlation between Rubicon and fatty liver disease.
White Papers
White Paper: Autophagy Research: Current Status and Future PerspectivesThis white paper, authored by Dr. Noboru Mizushima of the University of Tokyo, describes the current state of autophagy research and future areas of research and drug discovery. He discusses the impact of the discovery of ATG genes in autophagy research, the role of autophagy in disease, and the development of therapeutics targeting the autophagy pathway.
Blog
Blog: LC3: The gold standard for autophagy researchLC3, a mammalian homologue of yeast ATG8, is a soluble protein that is distributed ubiquitously in mammalian tissues and cultured cells. LC3 has been studied most extensively and is frequently used as an autophagy marker in mammals. Newly translated LC3 (proLC3) is immediately processed at the C-terminus in order to form LC3-I. During autophagy, autophagosomes engulf cytoplasmic components, including cytosolic proteins and organelles. Concomitantly, a cytosolic form of LC3 (LC3-I) is conjugated to phosphatidylethanolamine to form LC3-phosphatidylethanolamine conjugate (LC3-II), which is recruited to autophagosomal membranes.
Blog
Blog: Give Your Research 100% With a S100 AntibodyS100 proteins are a family of proteins known for their role in a variety of cellular pathways and diseases. This blog post will catch you up on the latest research on these important proteins.
Pathway Posters
Pathway Poster: ApoptosisApoptosis, a form of programmed cell death, is not only a major process within normal homeostasis but is present in disease states such as cancer and many autoimmune and neurodegenerative diseases.
Blog
Blog: Is Wnt3a an essential component in organoid culture?Organoids are self-organized three-dimensional tissue cultures that are derived from mammalian pluripotent or adult stem cells. These in-vitro-grown cell clusters are given possibilities to replicate much of the complexity of an organ. There are potentially as many types of organoids as there are different tissues and organs. To date, researchers have been able to prepare brain, kidney, lung, intestine, stomach, liver and many more are developing.
Webinars
Webinar: Immune Monitoring with MHC Tetramers and QuickSwitch™ Rapid Tetramer TechnologyIn this presentation by Dr. Marc Delcommenne, you will learn about our immune monitoring technologies and more.
Videos
Video: MBL’s MHC TetramersThe best method for monitoring T cells for antigen specificity. *Only Human and Macaque HLA Class I Tetramers contain the alpha 3 mutation.
Brochures
Brochure: Immutex™ Latex BeadsImmutex™ is a uniform-sized polystyrene latex (PSL) particle for agglutination tests in clinical diagnostics.
Videos
Video: MHC TetramersAn overview of MHC tetramers including Class I and Class II tetramers.. *Only Human and Macaque HLA Class I Tetramers contain the alpha 3 mutation.
Brochures
Brochure: Afamin/Wnt3a Condition Medium-Organoid Cell CultureBy using Afamin and Wnt3a complex for organoid culture, long term culture of organoid becomes possible. This new medium will result in optimal success for your organoid experiments.
Brochures
Brochure: Class II TetramersStay up to date with Class II tetramer offerings from MBLI. Detect CD4+ T Cell with ease and reliability
Videos
Video: Immunoprecipitation using SMART-IPMBL International Corporation offers a line of highly specific antibodies conjugated to magnetic beads. This method is an advantage over conventional immunoprecipitation of tagged proteins because it eliminates time consuming centrifugation steps. The magnetic beads are covalently bound to a Tag antibody and the beads are easily isolated using a magnetic rack.
Brochures
Brochure: ELISA Kits for Disease-related BiomarkersELISA Kits for Disease-related Biomarkers
Brochures
Brochure: p62 and phospho-p62 ELISA Kit, Autophagyp62 and phospho-p62 ELISA Kit, Autophagy
Brochures
Brochure: MHC Tetramers and Monomers for Immuno-Oncology and Autoimmunity Drug DiscoveryMHC Tetramers and Monomers for Immun-Oncology and Autoimmunity Drug Discovery
Brochures
Brochure: Immuno-OncologyThe combination of oncology research and immunology research (Immuno-Oncology) allows for a better understanding of how the immune system functions in relation to cancer.
Brochures
Brochure: QuickSwitch™ Custom Tetramers Kits-Class I MHC TetramersFast, High-Quality Creation of New MHC Tetramer Specificities
Videos
Video: Smart-IP: Tag antibodies conjugated to magnetic beadsMBL International Corporation offers a line of highly specific antibodies conjugated to magnetic beads.
Videos
Video: MHC Tetramers and antigen-specific T cell receptorsLearn more about our patented MHC multimer technology. *Only Human and Macaque HLA Class I Tetramers contain the alpha 3 mutation.
Videos
Video: RIP-Chip Assay for microRNAEducational video for RIP-Chip assay technology for microRNA. Identify miRNAs bound to their mRNA targets.
Brochures
Brochure: Tag AntibodiesEpitope tagging is a powerful and versatile method for detecting and purifying proteins expressed by cloned genes.
Brochures
Brochure: RIP-Chip; RNA-Binding Protein Immuno- precipitation for MicroarrayRIP-Chip is a technology used to identify functionally related mRNAs and other RNAs associated with RNA binding proteins (RBP).
Brochures
Brochure: NeuroscienceA comprehensive list of kits and antibodies for neuroscience research.
Brochures
Brochure: FUCCI (Fluorescence Ubiquitination-based Cell Cycle Indicator)Fucci is a set of fluorescent probes which enable the visualization of cell cycle progression in living cells.
