Reagents for COVID-19

SARS-CoV-2 is the virus that causes the COVID-19 disease (Coronovirus Disease 2019).  MBLI understands the urgent need to have better understanding and characterization of this disease.  We are continuing to develop and launch new products for the research community as fast as we can.

MBLI offers SMITEST for RNA extraction from various sample types.  RT-PCR (reverse transcription polymerase chain reaction) tests are commonly used to detect the SARS-CoV-2 virus.  FLUOROSEARCH is an RT-PCR detection kit readily available for detecting this virus within 1.5 hours.

T-cells are activated only by interacting with processed peptides (e.g. of SARS-CoV-2) that sit in the groove of MHC Class I and II molecules. Identifying these peptides can be used (in forms of peptide-MHC tetramers) to asses vaccine induced immunity and assist in designing potent vaccines with durable responses. COVID-19 infected cells can be recognized by T-cells only after SARS-CoV-2 peptides are processed and presented in the context of self MHCs.

Identifying these peptides have essential utilities:

  • Immune monitoring:  Using peptide-MHC tetramers to assess vaccine-induced immunity
  • Designing potent vaccines that elicit durable responses

MBL International can assist companies and academic investigators who are actively developing coronavirus vaccines with our unique QuickSwitch™ custom tetramer platform.  QuickSwitch™ is a peptide screening plug and play platform that identifies peptides that are more likely to be immunogenic and yet generates corresponding Class I and Class II MHC tetramers.  This platform can identify and validate multi-epitope candidates of SARS-CoV-2 proteins that can potentially elicit for both CD4+ and CD8+ T-cell immune responses. By using MBLI’s MHC tetramer exchange QuickSwitch™ platform for peptide screening, you can identify/validate the binding of predicted peptide sequences of the COVID-19 viral proteins in most common alleles: HLA-A2, A11, A24, A3 and HLA-DR1, DR4, DR15.

Product Highlights

MHC Tetramers for COVID-19 Cell Detection

Product CodeClassSequenceTarget
TB-0174-1Class IRLNEVAKNLHLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0174-2Class IRLNEVAKNLHLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0174-4Class IRLNEVAKNLHLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0174-MClass IRLNEVAKNLBiotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer
TB-0174-M2Class IRLNEVAKNLBiotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer
TB-0175-1Class IKLPDDFTGCVHLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0175-2Class IKLPDDFTGCVHLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0175-4Class IKLPDDFTGCVHLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0175-MClass IKLPDDFTGCVBiotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer
TB-0175-M2Class IKLPDDFTGCVBiotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer
TB-0176-1Class IYLQPRTFLLHLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0176-2Class IYLQPRTFLLHLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0176-4Class IYLQPRTFLLHLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0176-MClass IYLQPRTFLLBiotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer
TB-0176-M2Class IYLQPRTFLLBiotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer
TB-0177-1Class IRLQSLQTYVHLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer-
TB-0177-2Class IRLQSLQTYVHLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer-
TB-0177-4Class IRLQSLQTYVHLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer-
TB-0177-MClass IRLQSLQTYVBiotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer
TB-0177-M2Class IRLQSLQTYVBiotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer

Immune Detection Reagents for COVID-19 Research

Product CodeClassSequenceTargetProduct Type
SPC031Class INYLKRRVVFCOVID-19 ORF1ab (3159-3167)Peptide
SPC030Class IFYGGWHNMLCOVID-19 ORF1ab (4986-4994)Peptide
SPC029Class IDYVYNPFMICOVID-19 ORF1ab (6159-6167)Peptide
SPC028Class ITTIKPVTYKCOVID-19 ORF1ab (1875-1883)Peptide
SPC027Class ISTFNVPMEKCOVID-19 ORF1ab (2600-2608)Peptide
SPC026Class IKTFPPTEPKCOVID-19 nucleocapsid phosphoprotein (362-370)Peptide
SPC025Class IKSAGFPFNKCOVID-19 ORF1ab (4892-4900)Peptide
SPC024Class IASMPTTIAKCOVID-19 ORF1ab (2192-2200)Peptide
SPC023Class IYLYALVYFLCOVID-19 ORF3a protein (107-115)Peptide
SPC022Class IYLNTLTLAVCOVID-19 ORF1ab (6851-6859)Peptide
SPC021Class IYLDAYNMMICOVID-19 ORF1ab (6419-6427)Peptide
SPC020Class ITLMNVLTLVCOVID-19 ORF1ab (3710-3718)Peptide
SPC019Class ISMWALIISVCOVID-19 ORF1ab (3732-3740)Peptide
SPC018Class ILLYDANYFLCOVID-19 ORF3a protein (139-147)Peptide
SPC017Class ILLLDDFVEIICOVID-19 ORF1ab (6749-6758)Peptide
SPC016Class IFLLNKEMYLCOVID-19 ORF1ab (3183-3191)Peptide
SPC015Class IFLAHIQWMVCOVID-19 ORF1ab (3122-3130)Peptide
SPC014Class IIYFTSDYYQLYSTQLSCOVID-19 ORF3a protein (206-220)Peptide
SPC013Class IIWPQIAQFAPSASAFFCOVID-19 nucleocapsid phosphoprotein (301-315)Peptide
SPC012Class IITRFQTLLALHRSYLTCOVID-19 chain A spike glycoprotein (236-250)Peptide
SPC011Class IISEFSSLPSYAAFATACOVID-19 ORF1ab polyprotein (3946-3960)Peptide
SPC010Class IIRAMPNMLRIMASLVLCOVID-19 ORF1ab polyprotein (5016-5030)Peptide
SPC009Class IIMWLSYFIASFRLFARCOVID-19 membrane glycoprotein (91-105)Peptide
SPC008Class IIMDLFMRIFTIGTVTLCOVID-19 ORF3a protein (1-15)Peptide
SPC007Class IILSYYKLGASQRVAGDCOVID-19 membrane glycoprotein (176-190)Peptide
SPC006Class IILLLLDRLNQLESKMSCOVID-19 nucleocapsid phosphoprotein (221-235)Peptide
SPC005Class IILEASFNYLKSPNFSKCOVID-19 ORF1ab polyprotein (2211-2225)Peptide
SPC004Class IIFYVYSRVKNLNSSRVCOVID-19 envelope protein (56-70)Peptide
SPC003Class IIESPFVMMSAPPAQYECOVID-19 ORF1ab polyprotein (1801-1815)Peptide
SPC002Class IIEEIAIILASFSASTSCOVID-19 ORF1ab polyprotein (471-485)Peptide
SPC001Class IIEAFEKMVSLLSVLLSCOVID-19 ORF1ab polyprotein (3906-3920)Peptide

Learn more about COVID-19 by reading our blog post

COVID-19 Blog

Contact us today if you have specific needs that you do not see listed here. We’re here to help advance your COVID-19 research.

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