T-Select HLA-A*24:02 Negative (HIV env) Tetramer-RYLRDQQLL-FITC

Specifications:

Description

MHC Tetramers are used for the detection of antigen-specific T-cell populations. MHC-peptide tetramer complexes recognize antigen specific T-cells at the single cell level, allowing for accurate measurements of the functional immune response in cancer, infectious diseases, and autoimmune diseases.  Due to their increased avidity, MHC tetramers stably bind to cognate TcRs and are evaluated using flow cytometry.

Target: Negative (HIV)
Product Type: Tetramer
Size: 50 tests
Application: FCM
Research Area / Disease: Immune Monitoring, Immunology
Class: Class I
Allele: HLA-A*24:02
Peptide Sequence: RYLRDQQLL
Conjugate: FITC
Species Reactivity: Human
Specificity: env
Storage Temperature: 4°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Citations

  1. Akiyama Y, et al. J Transl Med 3: 4-13 (2005)
  2. Kozako T, et al. J Immunol 177: 5718-5726 (2006)
  3. Akimoto M, et al. J. Med Virol 79: 977-86 (2007)
  4. Tsuruma T, et al. J Transl Med 6: 24 (2008)
  5. Tsukahara T, et al. Cancer Sci 99: 368-375 (2008)
  6. Kozako T, et al. Leukemia 23: 375-382 (2009)
  7. Akiyama Y, et al. Anticancer Res 29: 647-655 (2009)
  8. Kameshima H, et al. Cancer Sci 102: 1181-1187 (2011)
  9. Kameshima H, et al. Cancer Sci 104: 124-129 (2013)
  10. Tezuka K, et al. Blood 123: 346-355 (2014)
  11. Koido S, et al. Clin Cancer Res 20: 4228-4239 (2014, MBL)
  12. Satomi F, et al. Int J Cancer Clin Res 2: 1-6 (2015, MBL)
  13. Tanaka T, et al. Cancer Sci. 106: 18-24 (2015)
  14. Najima Y, et al. Blood 127: 722-734 (2016, MBL)
  15. Murata K et al. OncoImmunology DOI:10.1080/2162402X.2016.1165376
  16. Shima H et al. Case report: Long-term survival of a pancreatic cancer patient immunized with an SVN-2B peptide vaccine. Cancer Immunol Immunother. 67, 1603-1609 (2018)
  17. Watanabe K et al. Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients. Cancer Sci. 110, 40-51 (2019)

References

  1. Kubota, H., et al., J. Immunol. 145, 3924-3931 (1990)
  2. Hans et al, GWAS_Supplementary Information
  3. Asthma GWAS paper_Nat Comm