QuickSwitch™ Quant HLA-DRB1*04:01 Tetramer Kit-APC

Specifications:

Description

The QuickSwitch™ Class II Tetramer Peptide Exchange and Quantitation Kit utilizes a patented technique for exchanging up to ten peptides on MHC class II molecules. Reduce time and cost with this kit to create your own custom tetramers.  The resulting custom tetramers can be used for multiple applications, including screening immunogenic peptides.

Target: Custom
Product Type: Tetramer
Size: 10 test
Application: FCM
Research Area / Disease: Immune Monitoring, Immunology
Class: Class II
Allele: DRB1*04:01
Peptide Sequence: Custom
Conjugate: APC
Species Reactivity: Human
Specificity: Custom
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Citations

  1. Sydney X. Lu, Emma de Neef, James D. Thomas, Luis Diaz, Jr., Omar Abdel-Wahab, Robert K. Bradley.  (2021) Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell, 12066.  Available at: /https://www.sciencedirect.com/science/article/abs/pii/S0092867421006905
  2. Hu, C., Shen, M., Han, X., Chen, Q., Li, L., Chen, S., . . . Jin, A. (2021). Identification of Cross-Reactive CD8 T Cell Receptors with High Functional Avidity to a SARS-CoV-2 Immunodominant Epitope and Its Natural Mutant Variants. Genes & Diseases. Available at: https://www.sciencedirect.com/science/article/pii/S2352304221000842
  3. Han, J., Yu, R., Duan, J., Li, J., Zhao, W., Feng, G., . . . Wang, J. (2021). Weighting tumor-specific TCR repertoires as a classifier to stratify the immunotherapy delivery in non–small cell lung cancers. Science Advances, 7(21).  Available at: https://advances.sciencemag.org/content/7/21/eabd6971
  4. Teng Wei, Matthias Leisegang, Ming Xia, Kazuma Kiyotani, Ning Li, Chenquan Zeng, Chunyan Deng, Jinxing Jiang, Makiko Harada, Nishant Agrawal, Liangping Li, Hui Qi, Yusuke Nakamura & Lili Ren (2021) Generation of neoantigen-specific T cells for adoptive cell transfer for treating head and neck squamous cell carcinoma, OncoImmunology, 10:1, Available at: https://www.tandfonline.com/doi/full/10.1080/2162402X.2021.1929726
  5. Poluektov, Y., Daftarian, P., & Delcommenne, M. C. (2020). Assessment of SARS-CoV-2 Specific CD4( ) and CD8 ( ) T Cell Responses Using MHC Class I and II Tetramers. Biorxiv Available at: https://www.biorxiv.org/content/10.1101/2020.07.08.194209v1://www.biorxiv.org/content/10.1101/2020.07.08.194209v1
  6. Son, E. T., Faridi, P., Paul-Heng, M., Leong, M., English, K., Ramarathinam, S. H., . . . Sharland, A. F. (2020). The self-peptide repertoire plays a critical role in transplant tolerance induction. Biorxiv. Available at: https://whttps://www.biorxiv.org/content/10.1101/2020.11.09.359968v2ww.biorxiv.org/content/10.1101/2020.11.09.359968v2
  7. Zhang, Y., Zhang, J., Chen, Y., Luo, B., Yuan, Y., Huang, F., . . . Zhang, H. (2020). The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I. Biorxiv. Available at: https://www.biorxiv.org/content/10.1101/2020.05.24.111823v1/www.biorxiv.org/content/10.1101/2020.05.24.111823v1
  8. Najafabadi, A. H., Zhang, J., Aikins, M. E., Abadi, Z. I., Liao, F., Qin, Y.,  Moon, J. J. (2020). Cancer Immunotherapy via Targeting Cancer Stem Cells Using Vaccine Nanodiscs. Nano Letters, 20(10), 7783-7792. Available at: https://pubs.acs.org/doi/10.1021/acs.nanolett.0c03414://pubs.acs.org/doi/10.1021/acs.nanolett.0c03414
  9. Song, X., Lu, Z., & Xu, J. (2020). Targeting cluster of differentiation 47 improves the efficacy of anti‑cytotoxic T‑lymphocyte associated protein 4 treatment via antigen presentation enhancement in pancreatic ductal adenocarcinoma. Experimental and Therapeutic Medicine. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444377/s://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444377/
  10. Lo, W., Parkhurst, M., Robbins, P. F., Tran, E., Lu, Y., Jia, L., . . . Rosenberg, S. A. (2019). Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer. Cancer Immunology Research, 7(4), 534-543 Available at: https://cancerimmunolres.aacrjournals.org/content/7/4/534
  11. Dustin, M. L., & Mayya, V. (2019). Faculty Opinions recommendation of T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature. Available at: https://pubmed.ncbi.nlm.nih.gov/31398327/
  12. Smith, C. C., Chai, S., Washington, A. R., Lee, S. J., Landoni, E., Field, K., . . . Vincent, B. G. (2019). Machine-Learning Prediction of Tumor Antigen Immunogenicity in the Selection of Therapeutic Epitopes. Cancer Immunology Research, 7(10), 1591-1604. Available at: https://cancerimmunolres.aacrjournals.org/content/7/10/1591.full-text.pdfps://cancerimmunolres.aacrjournals.org/content/7/10/1591.full-text.pdf
  13. Marc C Delcommenne, Olga Hrytsenko, Cynthia Tram, Genevieve Weir and Marianne M. Stanford. (2017) The QuickSwitch Quant HLA-A*02:01 Tetramer Kit can be used for determining the biological activity of a cancer vaccine. J Immunol, 198 (1 Supplement) 79.27 Available at: https://www.jimmunol.org/content/198/1_Supplement/79.27://www.jimmunol.org/content/198/1_Supplement/7