QuickSwitch™ HLA-A*02:01 Tetramer Kit-PE

Specifications:

Background

This QuickSwitch Starter Guide shows how to use our QuickSwitch kits with clear illustrations and step by step directions.

Contact us with any specific questions you may have!

Description

QuickSwitch™ Tetramer Kit utilizes a patented technique for exchanging up to ten peptides on an MHC class I tetramer. Reduce time and cost with this kit to create your own custom tetramers.  The resulting custom tetramers can be used for multiple applications, including screening immunogenic peptides.

Target: Custom
Product Type: Tetramer
Size: 25 µg
Application: FCM
Research Area / Disease: Immune Monitoring, Immunology
Class: Class I
Allele: HLA-A*02:01
Peptide Sequence: Custom
Conjugate: PE
Species Reactivity: Human
Specificity: Custom
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Citations

Zhang, Y., Zhang, J., Chen, Y., Luo, B., Yuan, Y., Huang, F., . . . Zhang, H. (2021). The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I. PNAS, 118(23). doi:10.1101/2020.05.24.111823

Marc C Delcommenne, Olga Hrytsenko, Cynthia Tram, Genevieve Weir and Marianne M. Stanford. (2017) The QuickSwitch Quant HLA-A*02:01 Tetramer Kit can be used for determining the biological activity of a cancer vaccine. J Immunol, 198 (1 Supplement) 79.27;

Kula, T., Dezfulian, M. H., Wang, C. I., Abdelfattah, N. S., Hartman, Z. C., Wucherpfennig, K. W., … Elledge, S. J. (2019). T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell, 178(4). DOI: 10.1016/j.cell.2019.07.009

Christof C. Smith, Shengjie Chai, Amber R. Washington, Samuel J. Lee, Elisa Landoni, Kevin Field, Jason Garness, Lisa M. Bixby, Sara R. Selitsky, Joel S. Parker, Barbara Savoldo, Jonathan S. Serody, and Benjamin G. Vincent (2019) Machine-Learning Prediction of Tumor Antigen Immunogenicity in the Selection of Therapeutic Epitopes dok: 10.1158/2326-6066.CIR-1900155

References

  1. Kubota, H., et al., J. Immunol. 145, 3924-3931 (1990)
  2. Hans et al, GWAS_Supplementary Information
  3. Asthma GWAS paper_Nat Comm