Products MHC Tetramers & Monomers QuickSwitch™ Custom Tetramer Kits QuickSwitch™ Quant HLA-A*02:01 Tetramer Kit-APC

QuickSwitch™ Quant HLA-A*02:01 Tetramer Kit-APC

Specifications:

Background

Description

QuickSwitch™ Tetramer Kit utilizes a patented technique for exchanging up to ten peptides on an MHC class I tetramer. Reduce time and cost with this kit to create your own custom tetramers or to test which peptide sequence has the best peptide-MHC binding affinity. This kit can be used for screening multiple peptides or to create a small amount of your own custom Tetramer in house. The resulting custom tetramers can be used for multiple applications including screening immunogenic peptides, neoantigen discovery, and many other assays downstream from in-silico selection.

FAQs for Peptide Exchange using QuickSwitch™ Kit

Target:	Custom
Product Type:	Tetramer
Size:	1 kit
Application:	FCM
Research Area / Disease:	Immune Monitoring, Immunology
Class:	Class I
Allele:	HLA-A*02:01
Peptide Sequence:	Custom
Conjugate:	APC
Species Reactivity:	Human
Specificity:	Custom
Regulatory Statement:	For Research Use Only. Not for use in diagnostic procedures.

Citations

Zhang, Y., Zhang, J., Chen, Y., Luo, B., Yuan, Y., Huang, F., . . . Zhang, H. (2020). The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I. Biorxiv. doi:10.1101/2020.05.24.111823

Lo, W., Parkhurst, M., Robbins, P. F., Tran, E., Lu, Y., Jia, L., . . . Rosenberg, S. A. (2019). Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer. Cancer Immunology Research, 7(4), 534-543. doi:10.1158/2326-6066.cir-18-0686

Poluektov, Y., Daftarian, P., & Delcommenne, M. C. (2020). Assessment of SARS-CoV-2 Specific CD4( ) and CD8 ( ) T Cell Responses Using MHC Class I and II Tetramers. Biorxiv. doi:10.1101/2020.07.08.194209

Dustin, M. L., & Mayya, V. (2019). Faculty Opinions recommendation of T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature. doi:10.3410/f.736361281.793566682