Products MHC Tetramers & Monomers MHC Tetramers MHC Class I iTAg Tetramer/PE – H-2 Kb TRP2 (SVYDFFVWL)

iTAg Tetramer/PE – H-2 Kb TRP2 (SVYDFFVWL)

Specifications:

Description

MHC Tetramers are used for the detection of antigen-specific T-cell populations. MHC-peptide tetramer complexes recognize antigen specific T-cells at the single cell level, allowing for accurate measurements of the functional immune response in cancer, infectious diseases, and autoimmune diseases. Due to their increased avidity, MHC tetramers stably bind to cognate TcRs and are evaluated using flow cytometry.

Target:	Cancer/Melanoma
Product Type:	Tetramer
Size:	50 tests
Application:	FCM
Research Area / Disease:	Immune Monitoring, Immunology
Class:	Class I
Allele:	H-2Kb
Peptide Sequence:	SVYDFFVWL
Conjugate:	PE
Species Reactivity:	Mouse
Specificity:	TRP2 (mouse)

Citations

Kuwada E, et al., Anticancer Res. 31: 881−891 (2011)
Aleksey K. Molodtsov, Nikhil Khatwani, Jennifer L. Vella, Kathryn A. Lewis, Yanding Zhao, Jichang Han, Delaney E. Sullivan, Tyler G. Searles, Nicholas K. Preiss, Tamer B. Shabaneh, Peisheng Zhang, Aaron R. Hawkes, Brian T. Malik, Fred W. Kolling, Edward J. Usherwood, Sandra L. Wong, Joseph D. Phillips, Keisuke Shirai, Christina V. Angeles, Shaofeng Yan, Tyler J. Curiel, Yina H. Huang, Chao Cheng, Mary Jo Turk. (2021) Resident memory CD8+ T cells in regional lymph nodes mediate immunity to metastatic melanoma. Immunity. doi: 10.1016/j.immuni.2021.08.019