iTAg Tetramer/PE – HLA-A*02:01 Mart-1 (ELAGIGILTV)

Specifications:

Description

MHC Tetramers are used for the detection of antigen-specific T-cell populations. MHC-peptide tetramer complexes recognize antigen specific T-cells at the single cell level, allowing for accurate measurements of the functional immune response in cancer, infectious diseases, and autoimmune diseases.  Due to their increased avidity, MHC tetramers stably bind to cognate TcRs and are evaluated using flow cytometry.

Target: Cancer/Melanoma
Product Type: Tetramer
Size: 50 tests
Application: FCM
Research Area / Disease: Immune Monitoring, Immunology
Class: Class I
Allele: HLA-A*02:01
Peptide Sequence: ELAGIGILTV
Conjugate: PE
Species Reactivity: Human
Specificity: Mart-1
Storage Temperature: 4°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Citations

  1. Mantovani S, et al. J Immunol 169: 6253-6260 (2002 BCI)
  2. Paczesny S, et al. J Exp Med 199: 1503-1511 (2004 BCI)
  3. Coughlin CM, et al. Blood 103: 2046-2054 (2004 BCI)
  4. Tomiyama M, et al. Anticancer Res. 24: 3327-3334 (2004, MBL)
  5. Akiyama Y, et al. J. Transl. Med. 3: 4-13 (2005)
  6. Casati C, et al. Cancer Res 66: 4450-4460 (2006 BCI)
  7. Sasawatari S, et al. Immunol Cell Biol 84: 512–521 (2006, MBL)
  8. Wong RM, et al. Int Immunol 19: 1223-1234 (2007 BCI)
  9. Takahara M, et al. J. Leukoc. Biol. 83: 742-754 (2008)
  10. Frleta D, et al. J. Immunol 182: 2766-2776 (2009 BCI)
  11. Alanio C, et al. Blood 115: 3718-3725 (2010 BCI)
  12. Banchereau J, et al. PNAS 109: 18885-18890 (2012 BCI)
  13. Bruns H, et al. Clin Cancer Res 21: 2075-2083 (2015, BCI)
  14. McCracken MN, et al. J Clin Invest 125: 1815–1826 (2015, MBL)
  15. Inozume T et al. Cytotoxic T-lymphocyte-associated protein 4 expressed by melanoma cells does not affect melanoma-specific cytotoxic T lymphocytes in the effector phase. J Dermatol. 46, 52-56 (2019)
  16. Nagano S et al. High Frequency Production of T Cell-Derived iPSC Clones Capable of Generating Potent Cytotoxic T Cells. Mol Ther Methods Clin Dev. 16, 126-135 (2019)
Code TB-0009-1
Product Type Tetramer
Size 50 tests
Application FCM
Price
$1,300.00
Qty: