Anti-Fas (CD95) mAb

  • Applications
    • FCM
    • WB
  • Target Fas
  • Host Species Mouse
  • Species Reactivities Human
  • Code # SY-001
  • Size 100 µl
  • Price
    $350.89
Specifications

Alternative Names

Fas (TNF receptor superfamily, member 6)

Background

It is now widely accepted that apoptosis plays an important role in the selection of immature thymocytes and Ag-primed peripheral T cells. Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has structural homology with a number of cell-surface receptors, including tumor necrosis factor receptor and nerve growth factor receptor.
  • Antibody Type:
    Monoclonal
  • Application:
    FCM, WB
  • Clone Number:
    CH-11
  • Conjugate:
    Unlabeled
  • Description:

    Monoclonal Antibody of 100 µl targeting Fas for FCM, WB.

  • Formulation:
    0.5 mg/mL in PBS/50% glycerol, pH 7.2
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Host Species:
    Mouse
  • Immunogen:
    FS-7 Human diploid fibroblasts
  • Isotype:
    IgM
  • Product Type:
    Antibody
  • Reactivity:
    This antibody induces apoptosis in human cell lines expressing Fas antigen
  • Research Area:
    Apoptosis
  • Short Description:

    Fas Monoclonal Antibody.

  • Size:
    100 µl
  • Species Reactivity:
    Human
  • Storage Temperature:
    -20°C
  • Target:
    Fas
Citations
  1. Murthy A et al. A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. Nature 506, 456-62 (2014),
  2. Zanin-Zhorov A et al. Fibronectin-associated Fas ligand rapidly induces opposing and time-dependent effects on the activation and apoptosis of T cells. J Immunol. 171, 5882-9 (2003)
  3. Yamaji, T., et al., J. Biol. Chem. 285, 35505-35518 (2010)
  4. Arokium, H., et al., J. Virol. 83, 11283-11297 (2009)
  5. Pallasch, C. P., et al., Blood 112, 4213-4219 (2008)
  6. Conus, S., et al., J. Exp. Med. 205, 685-698 (2008)
  7. Okamoto, K., et al., Genes Cells 11, 177-191 (2006)
  8. Ohgushi, M., et al., Mol. Cell. Biol. 25, 10017-10028 (2005)
  9. Kotone-Miyahara, Y., et al., J. Leukoc. Biol. 76, 1047-1056 (2004)
  10. Lee, K-K., et al., J. Biol. Chem. 276, 19276-19285 (2001)
  11. Ichikawa, K., et al., Int. Immunol. 12, 555-562 (2000)
  12. Tsukumo, S. I., et al., Genes Cells 4, 541-549 (1999)
  13. Yamashita, K., et al., Blood 93, 674-685 (1999)
  14. Ito, N., et al., Cell 66, 233-243 (1991)
  15. Kobayashi, N., et al., PNAS 87, 9620-9624 (1990)
  16. Yonehara, S., et al., J. Exp. Med. 169, 1747-1756 (1989)