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Anti-2,2,7-trimethylguanosine (m3G/TMG) mAb

RN019M
Antibody
200 μL

$429.85

DATA SHEET

Monoclonal Antibody of 200 µl targeting 2,2,7-trimethylguanosine (m3G/TMG) for IP, IC

Target2,2,7-trimethylguanosine
Product TypeAntibody
ApplicationICC, IP
ClonalityMonoclonal
ConjugateUnlabeled
IsotypeIgG2a ĸ
ImmunogenCarrier protein-conjugated trimethylguanosine (m3G/TMG)
Host SpeciesMouse
FormulationPBS containing 50% Glycerol (pH 7.2). No preservative is contained
Research AreaEpigenetics
Description/Background

Small nuclear RNA (snRNA) is known to be involved in pre-mRNA splicing as an RNA component of snRNP. 2,2,7-trimethylated guanosine (m3G/TMG) is a modified nucleoside at the 5’-cap site of U snRNAs except for U6 snRNA. Shortly after transcription, 7-methylguanosine (m7G), called cap structure, is added to 5’-end of newly synthesized U snRNA and m7G-capped U snRNA is exported to the cytoplasm. The m7G-cap is converted to m3G-cap, which is a hypermethylated structure of 5’-end, by cytoplasmic catalytic protein TSG1 and the m3G-capped U snRNA forms snRNP with Sm proteins in the cytoplasm, followed by entry into the nucleus. The m3G-capped snRNP plays a role in regulation of pre-mRNA splicing as a part of spliceosome in nucleus. It is also reported that U3 and U8 snoRNA, localized to Cajal body during RNP biogenesis, possess m3G-cap structure.

Storage Temperature-20°C
ProtocolsICC, IP
Clone Number235-1
Concentration1 mg/mL
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
RN019M
Antibody
200 μL

$429.85

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