Anti-IGF2BP3 (IMP3) (Human/Mouse) pAb (Polyclonal Antibody)

IGF2BP3/IMP3 Polyclonal Antibody.

Specifications:

Description

Polyclonal Antibody of 200 µl targeting IGF2BP3/IMP3 for IP, RIP, WB.

Target: IGF2BP3/IMP3
Product Type: Antibody
Size: 200 μl
Application: IP, RIP, WB
Research Area / Disease: Epigenetics
Conjugate: Unlabeled
Antibody Type: Polyclonal
Concentration: 1 mg/mL
Formulation: 200 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Immunogen: Peptide bond synthesis HQQQKALQSGPPQSRRK KLH (563-579 aa)
Host Species: Rabbit
Species Reactivity: Human, Mouse
Source: This antibody was purified from rabbit serum by affinity column chromatography. The rabbit was immunized with KLH conjugated synthetic peptide, HQQQKALQSGPPQSRRK corresponding to 563-579 aa.
Reactivity: This antibody reacts with human IGF2BP3 (~64 kDa) on Western blotting, Immunoprecipitation and RNP Immunoprecipitation.
Gene ID Human:

10643

Gene ID Mouse:

140488

Storage Temperature: '-20°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Citations

  1. Conway AE et al. Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival. Cell Rep. 15, 666-79 (2016),
  2. Degrauwe N et al. The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing. Cell Rep 15, 1634-47 (2016),
  3. Lederer M et al. The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer. Semin Cancer Biol. 29, 3-12 (2014),
  4. Pasiliao CC et al. The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesion. BMC Cancer 15, 266 (2015),
  5. Ueki A et al. Up-regulation of Imp3 confers in vivo tumorigenicity on murine osteosarcoma cells. PLoS One. 7, e50621 (2012)
  6. The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing.
    Derauwe N et al. Cell Rep. (2016) 
  7. Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival.
    Conway AE et al. Cell Rep. 15, 666-79 (2016) 
  8. RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation.
    Palanichamy JK et al. 

References

  1. Liao, B., et al., J. Biol. Chem. 280, 18517-18524 (2005)
  2. Monk, D., et al., J. Med. Genet. 39, 575-581 (2002)
  3. Nielsen, J., et al., Mol. Cell Biol. 19, 1262-1270 (1999)
  4. Mueller-Pillasch, F., et al., Oncogene 14, 2729-2733 (1997)