Anti-IGF2BP2 (IMP2) (Human) pAb (Polyclonal Antibody)

IGF2BP2/IMP2 Polyclonal Antibody.

Specifications:

Description

Polyclonal Antibody of 200 µl targeting IGF2BP2/IMP2 for IP, RIP, WB.

Target: IGF2BP2/IMP2
Product Type: Antibody
Size: 200 μl
Application: IP, RIP, WB
Research Area / Disease: Epigenetics
Conjugate: Unlabeled
Antibody Type: Polyclonal
Concentration: 1 mg/mL
Formulation: 200 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Immunogen: Peptide bond synthesis KQQEQKYPQGVASQRSK KLH (583-599 aa)
Host Species: Rabbit
Species Reactivity: Human, Mouse, Rat
Source: This antibody was purified from rabbit serum by affinity column chromatography. The rabbit was immunized with KLH conjugated synthetic peptide, KQQEQKYPQGVASQRSK corresponding to 583-599 aa.
Reactivity: This antibody reacts with human IGF2BP2 (~66 kDa) on Western blotting, Immunoprecipitation and RNP Immunoprecipitation.
Gene ID Human:

10644

Gene ID Mouse:

319765

Storage Temperature: '-20°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Citations

  1. Conway AE et al. Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival. Cell Rep. 15, 666-79 (2016),
  2. Degrauwe N et al. The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing. Cell Rep. 15, 1634-47 (2016),
  3. Gong C et al. A long non-coding RNA, LncMyoD, regulates skeletal muscle differentiation by blocking IMP2-mediated mRNA translation. Dev Cell. 34, 181-91 (2015),
  4. Janiszewska M et al. Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells. Genes Dev. 26, 1926-44 (2012),
  5. Schaeffer V et al. RNA-binding protein IGF2BP2/IMP2 is required for laminin-β2 mRNA translation and is modulated by glucose concentration. Am J Physiol Renal Physiol. 303, F75-82 (2012)
  6. The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing.
    Derauwe N et al. Cell Rep. (2016) 
  7. Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival.
    Conway AE et al. Cell Rep. 15, 666-79 (2016) 

References

  1. van Hoek, M. et al., Diabetes E publication, Mar 3, (2009)
  2. Nielsen, F. C., et al., Scand. J. Clin. Lab. Invest. Suppl. 234, 93-99 (2001)
  3. Nielsen, J., et al., Mol. Cell Biol. 19, 1262-1270 (1999)