p62 ELISA Kits and Antibodies
p62/SQSTM1 is thought to be a substrate that binds directly to LC3 causing its selective degradation by autophagy. The ubiquitin-conjugating protein p62/SQSTM1 is thought to be a scaffold protein because it interacts with a variety of molecules involved in toll-like receptor (TLR) signaling, such as TRAF6, ERK, and aPKC. Importantly, ubiquitin- and p62-positive inclusions have been detected in tissues from patients with neurodegenerative diseases (such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis), alcoholic hepatitis, fatty liver, or liver cancer.
An anti-p62/SQSTM1 antibody, which has a variety of applications including Western blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), and Immunohistochemistry (IHC), is useful for observation of p62-caused pathogenesis and dynamics at the molecular level.