Products Research Area/Disease Autophagy Reagents p62 ELISA Kits and Antibodies Anti-p62 (SQSTM1) (Human) pAb (Polyclonal Antibody)

Anti-p62 (SQSTM1) (Human) pAb (Polyclonal Antibody)

p62 Polyclonal Antibody.

Data Sheet

Specifications:

Description

This antibody is validated for multiple applications (WB, IHC, ICC and IP) and is widely cited, including in research papers with more than 200 citations (Waguri S, Komatsu M. Biochemical and morphological detection of inclusion bodies in autophagy-deficient mice. Methods Enzymol. 453, 181-96 (2009)). This is a polyclonal antibody of 100 μl that is raised in rabbit and is reactive with human, hamster, mouse, rat.

Target:	p62
Product Type:	Antibody
Size:	100 µl
Application:	ICC, IHC, IP, WB
Research Area / Disease:	Autophagy
Conjugate:	Unlabeled
Antibody Type:	Polyclonal
Formulation:	100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Isotype:	Affinity Purified Ig
Immunogen:	Recombinant human p62 (120-440 a.a.)
Host Species:	Rabbit
Species Reactivity:	Hamster, Human, Mouse, Rat
Source:	This antibody was purified from rabbit serum using affinity column. The rabbit was immunized with the recombinant human p62 protein corresponding to amino acids 120-440.
Reactivity:	This antibody reacts with p62 on Western blotting, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry.
Gene ID Human:	8878
Gene ID Mouse:	18412
Gene ID Rat:	113894
Storage Temperature:	-20°C
Regulatory Statement:	For Research Use Only. Not for use in diagnostic procedures.

Citations

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Cocco, Stefania, et al. “Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models.” Journal of Translational Medicine 20.1 (2022): 1-17.
Molero-Valenzuela, Adrià, et al. “A Novel Late-Stage Autophagy Inhibitor That Efficiently Targets Lysosomes Inducing Potent Cytotoxic and Sensitizing Effects in Lung Cancer.” Cancers 14.14 (2022): 3387.
Mawed, Suzan Attia, et al. “atg7 and beclin1 are essential for energy metabolism and survival during the larval-to-juvenile transition stage of zebrafish.” Aquaculture and Fisheries 7.4 (2022): 359-372.
Ono, Maiko, et al. “Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy.” Aging Cell (2022): e13615.
Agudo-Canalejo, Jaime, et al. “Wetting regulates autophagy of phase-separated compartments and the cytosol.” Nature 591.7848 (2021): 142-146.
Sukseree, Supawadee, et al. “Sequestosome 1/p62 enhances chronic skin inflammation.” Journal of Allergy and Clinical Immunology 147.6 (2021): 2386-2393.
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