Anti-Atg16L (Human) pAb (Polyclonal Antibody)

Atg16L Polyclonal Antibody.

Specifications:

Description

Polyclonal Antibody of 100 µg targeting Atg16L for ICC, IP, WB.

Target: Atg16L
Product Type: Antibody
Size: 100 μg
Application: ICC, IP, WB
Research Area / Disease: Autophagy
Conjugate: Unlabeled
Antibody Type: Polyclonal
Formulation: 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Isotype: Affinity Purified Ig
Immunogen: Recombinant human ATG16L1 TV2 (85-588 a.a.)
Host Species: Rabbit
Species Reactivity: Hamster, Human, Mouse, Rat
Source: This antibody was purified from rabbit serumusing affinity column. The rabbit was immunized with therecombinant human ATG16L1 TV2 (85-588 aa).
Reactivity: This antibody reacts with Atg16L onWestern blotting, Immunoprecipitation andImmunocytochemistry.
Gene ID Human:

55054

Gene ID Mouse:

77040

Gene ID Rat:

363278

Storage Temperature: '-20°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Citations

  1. Matsunaga K et al. Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J Cell Biol. 190, 511-21 (2010),
  2. Moreau K et al. Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D. J Cell Biol. 196, 483-96 (2012),
  3. Murthy A et al. A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3. Nature 506, 456-62 (2014),
  4. Takahashi Y et al. Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy. Autophagy 7, 61-73 (2011),
  5. Young MM et al. Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis. J Biol Chem. 287, 12455-68 (2012)
    1. Runwal, G., Stamatakou, E., Siddiqi, F. et al. LC3-positive structures are prominent in autophagy-deficient cells. Sci Rep 9, 10147 (2019)
    2. Takahashi Y et al. An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure. Nat Commun. 9, 2855 (2018)
    3. Pavel M et al. Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis. Nat Commun. 9, 2961 (2018)
    4. Fahmy AM et al. LC3B is not recruited along with the autophagy elongation complex (ATG5-12/16L1) at HCV replication site and is dispensable for viral replication. PLoS One. 13, e0205189 (2018)
    5. Ding X et al. RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. Autophagy. 15, 1774-1786 (2019)rn
    6. Zemirli N et al. The primary cilium protein folliculin is part of the autophagy signaling pathway to regulate epithelial cell size in response to fluid flow. Cell Stress. 3, 100-109 (2019)
    7. Scrivo A et al. Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production. Nat Commun. 10, 780 (2019

    References

    1. Murthy, A., et al., Nature 506, 456-462 (2014) [IP]
    2. Young, M. M., et al., J.Biol.Chem. 287, 12455-12468 (2012)[IC]
    3. Moreau, K., et al., J. Cell Biol. 196, 483-496 (2012) [IC]
    4. Takahashi, Y., et al., Autophagy 7, 61-73 (2011) [IC]
    5. Matsunaga, K., et al., J. Cell Biol. 190, 511-521 (2010) [IC]
    6. Matsushita, M., et al., J. Biol. Chem. 282, 6763-6772 (2007)