Anti-IL-18 (Human) pAb (Polyclonal Antibody)



Interleukin 18 (IL-18) is an 18 kDa cytokine which identified as a costimulatory factor for
production of interferon-gamma (IFN-gamma) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24 kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-gamma is produced by activated T or NK cells and plays critical roles in the defense against microbial pathogens. IFN-gamma activates macrophages, enhances NK activity and B cell maturation, proliferation and Ig secretion, induces MHC class I and II antigens, and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-gamma. Pleiotropic effects of IL-18 has also been reported, such as, enhancement production of IFN-gamma and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF and IFN-gamma in T cells, enhancement of Fas ligand expression by Th1 cells.


Polyclonal Antibody  targeting IL-18 for IHC, WB.

Target: IL-18
Product Type: Antibody
Size: 100 uL
Application: IHC, WB
Research Area / Disease: Immunology
Conjugate: Unlabeled
Antibody Type: Polyclonal
Isotype: IgG
Host Species: Rabbit
Species Reactivity: Human


  1. Allam O et al. HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation. PLoS One 13, e0194185 (2018)
  2. Ashida H et al. A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase-8. EMBO J. 39, e104469 (2020)
  3. Hirano H et al. TLR4, IL-6, IL-18, MyD88 and HMGB1 are highly expressed in intracranial inflammatory lesions and the IgG4/IgG ratio correlates with TLR4 and IL-6. Neuropathology 32, 628-37 (2012),
  4. Komsky A et al. Presence of IL-18 in testicular tissue of fertile and infertile men. Andrologia 44, 1-8 (2012)


  1. Dao, T., et al., Cell Immunol. 173, 230-235 (1996)
  2. Micallef, M., et al., Eur. J. Immunol. 26, 1647-1651 (1996)
  3. Ushio, S., et al. J., Immunol. 156, 4274-4279 (1996)
  4. Okamura, H., et al., Nature 378, 88-91 (1995)
Code PM014
Product Type Antibody
Size 100 uL
Application IHC, WB