Anti-IL-18 (Human) pAb

  • Applications
    • IHC
    • WB
  • Target IL-18
  • Host Species Rabbit
  • Species Reactivities Human
  • Code # PM014
  • Size 100 µg
  • Price
    $261.78
Specifications

Alternative Names

interleukin 18 (interferon-γ-inducing factor), IGIF, IL1F4, IL-1g, IL-18

Background

Interleukin 18 (IL-18) is a 18 kDa novel cytokine which identified as a co-stimulatory factor for production of interferon-γ (IFN-γ) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24 kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalons. IFN-γ is produced by activated T or NK cells and plays critical roles in the defense against microbial pathogens. IFN-γ activates macrophages, enhances NK activity and B cell maturation, proliferation and Ig secretion, induces MHC class I and II antigens, and inhibits osteoclast activation. IL-18 acts on T helper 1-type T cells and, in combination with IL-12, strongly induces them to produce IFN-γ. Pleiotropic effects of IL-18 has also been reported, such as, enhancement production of IFN-γ and GM-CSF in peripheral blood mononuclear cells, production of T helper type 1 cytokines, IL-2, GM-CSF and IFN-γ in T cells, enhancement of Fas ligand expression by T helper type 1 cells.
  • Antibody Type:
    Polyclonal
  • Application:
    IHC, WB
  • Concentration:
    1 mg/mL
  • Conjugate:
    Unlabeled
  • Description:

    Polyclonal Antibody of 100 µg targeting IL-18 for IHC, WB.

  • Formulation:
    100 μl volume of PBS containing 50% glycerol, pH 7.2. Contains no preservatives.
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Host Species:
    Rabbit
  • Immunogen:
    Recombinant human IL-18
  • Isotype:
    IgG
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with human IL-18(18kDa) on Western blotting.
  • Research Area:
    Immunology
  • Short Description:
    Description not found
  • Size:
    100 µg
  • Species Reactivity:
    Human
  • Storage Temperature:
    -20°C
  • Target:
    IL-18
Citations
  1. Hirano H et al. TLR4, IL-6, IL-18, MyD88 and HMGB1 are highly expressed in intracranial inflammatory lesions and the IgG4/IgG ratio correlates with TLR4 and IL-6. Neuropathology 32, 628-37 (2012),
  2. Komsky A et al. Presence of IL-18 in testicular tissue of fertile and infertile men. Andrologia 44, 1-8 (2012)
References
  1. Dao, T., et al., Cell Immunol. 173, 230-235 (1996)
  2. Micallef, M., et al., Eur. J. Immunol. 26, 1647-1651 (1996)
  3. Ushio, S., et al. J., Immunol. 156, 4274-4279 (1996)
  4. Okamura, H., et al., Nature 378, 88-91 (1995)