Anti-Pax6 (Mouse) (Mouse) pAb

  • Applications
    • IHC
    • WB
  • Target Pax6
  • Host Species Rabbit
  • Species Reactivities Chicken, Mouse, Rat
  • Code # PD022
  • Size 100 µl
  • Price
    $289.63
Specifications

Alternative Names

paired box gene 6

Background

Pax6 is a transcription factor that was first identified as a member of paired box (Pax) family protein and functions as the master gene controlling eye development. The mammalian Pax6 locus encodes at least three isoforms, the “canonical” Pax6, Pax6(5a), and Pax6(ΔPD). Pax6 is also involved in various phenomena during development of the central nervous system, including patterning of the neural tube, migration of neurons, and formation of neural circuits. During development, Pax6 is expressed in neuroepithelial cells in the ventricular zone of the brain primordium and regulates proliferation and differentiation through the control of expression of different downstream factors such as FABP7 and Neurogenin2. On the other hand, Pax6 is expressed in neural stem/progenitor cells in the subgaranular zone of the hIPocampal dentate gyrus and the subventricular zone (SVZ) of the lateral ventricule throughout adult. Furthermore, intense expression of Pax6 is detected in SVZ-derived immature migrating neurons, cerebellar granule cells, precerebellar neurons and astrocytes in the cerebral cortex and spinal cord.
  • Antibody Type:
    Polyclonal
  • Application:
    IHC, WB
  • Conjugate:
    Unlabeled
  • Description:

    Polyclonal Antibody of 100 µl targeting Pax6 for IHC, WB.

  • Formulation:
    100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Gene ID (Rat):
  • Host Species:
    Rabbit
  • Immunogen:
    C-terminal peptide of mouse Pax6 (420-436 aa)
  • Isotype:
    Affinity Purified Ig
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with Pax6 on Western blotting and Immunohistochemistry. Additionally, it reacts with canonical Pax6 and Pax6(5a) in mouse embryonic cortex on Western blotting.
  • Research Area:
    Neuroscience
  • Short Description:

    Pax6 Polyclonal Antibody.

  • Size:
    100 µl
  • Species Reactivity:
    Chicken, Mouse, Rat
  • Storage Temperature:
    -20°C
  • Target:
    Pax6
Citations
  1. Imaizumi K et al. Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes. Stem Cell Reports 5, 1010-22 (2015),
  2. Li X et al. Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary in the spinal cord. Development 141, 2875-84 (2014),
  3. Liu T et al. Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing. PLoS One. 7, e46934 (2012),
  4. Ma T et al. A subpopulation of dorsal lateral/caudal ganglionic eminence-derived neocortical interneurons expresses the transcription factor Sp8. Cereb Cortex. 22, 2120-30 (2012),
  5. Yamada T et al. Establishment of a recessive mutant small-rat with lens involution and retinal detachment associated with partial deletion and rearrangement of the Cryba1 gene. Biochem J. 471, 293-305 (2015)(PMID:26303524),
  6. Zhou X et al. Transcription factors COUP-TFI and COUP-TFII are required for the production of granule cells in the mouse olfactory bulb. Development 142, 1593-605 (2015)
  7. Li, X., et al., Development 141, 2875-2884 (2014) [IHC]
  8. Liu, T., et al., PLos One 7, e46934 (2012) [IF]
  9. Ma, T., et al., Cereb. Cortex 22, 2120-2130 (2012) [IHC]
References
  1. Sakurai, K., and Osumi, N., J. Neurosci. 28, 4604-4612 (2008)
  2. Osumi, N., et al., Stem Cells 26, 1663-1672 (2008)
  3. Nomura, T., et al., PLoS ONE 3, e1454 (2008)
  4. Maekawa, M., et al., Genes Cells 10, 1001-1114 (2005)
  5. Takahashi, M., and Osumi, N.,Development 129, 1327-1338 (2002)
  6. Matsunaga, E., et al., Development, 127, 2357-2365 (2000)
  7. Inoue, T., et al., Dev Biol, 219, 373-383 (2000)