Anti-Beclin 1 (Human) pAb (Polyclonal Antibody)

Specifications:

Description

Target: Beclin 1
Product Type: Antibody
Size: 100 μg
Application: ICC, IP, WB
Research Area / Disease: Autophagy
Conjugate: Unlabeled
Antibody Type: Polyclonal
Formulation: In PBS/50% glycerol, pH 7.2
Isotype: Affinity Purified Ig
Immunogen: Full-length recombinant human Beclin 1
Host Species: Rabbit
Species Reactivity: Hamster, Human, Mouse, Rat
Reactivity: This antibody reacts with Beclin 1 on Western blotting, Immunoprecipitation and Immunocytochemistry.
Storage Temperature: '-20°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Citations

  1. Berliocchi L et al. Autophagy impairment in a mouse model of neuropathic pain. Mol Pain. 7, 83 (2011),
  2. Hamasaki M et al. Autophagosomes form at ER-mitochondria contact sites. Nature 495, 389-93 (2013),
  3. Matsunaga K et al. Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J Cell Biol. 190, 511-21 (2010),
  4. Russo R et al. Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo. Cell Death Dis. 2, e144 (2011)
    1. Lin X et al. Liver-specific deletion of Eva1a/Tmem166 aggravates acute liver injury by impairing autophagy. Cell Death Dis. 9, 768 (2018)
    2. Zhang Yet al. TGF-β3 Promotes MUC5AC Hyper-Expression by Modulating Autophagy Pathway in Airway EBioMedicine. 33, 242-252 (2018)
    3. Hagio-Izaki K et al. Lipopolysaccharide induces bacterial autophagy in epithelial keratinocytes of the gingival sulcus. BMC Cell Biol. 19, 18 (2018)
    4. Jin GL et al. Koumine Decreases Astrocyte-Mediated Neuroinflammation and Enhances Autophagy, Contributing to Neuropathic Pain From Chronic Constriction Injury in Rats. Front Pharmacol. 9, 989 (2018)
    5. Sase K et al. Involvement of Beclin‑1 in axonal protection by short‑term hyperglycemia against TNF‑induced optic nerve damage. Mol Med Rep. 18, 5455-5460 (2018)
    6. Wang M et al. WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling. Mol Psychiatry (2018) In press
    7. Nakajima S et al. Fat-specific protein 27α inhibits autophagy-dependent lipid droplet breakdown in white adipocytes. J Diabetes Investig. in press.
    8. Shen J et al. Role of Autophagy in Zinc Oxide Nanoparticles-Induced Apoptosis of Mouse LEYDIG Cells. Int J Mol Sci. 20, pii: E4042 (2019)