Anti-Beclin 1 (Human) pAb

  • Applications
    • ICC
    • IP
    • WB
  • Target Beclin 1
  • Species Reactivities Hamster, Human, Mouse, Rat
  • Code # PD017
  • Size 100 μg
  • Price
    $301.22
Specifications

Background

Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. Beclin 1, the mammalian homologue of yeast Atg6, was first identified Bcl-2-interacting protein. Beclin 1 localizes to the trans-Golgi network, and forms a complex with phosphatidylinositol 3-kinase. Beclin 1 is essential for early autophagosome formation.
  • Antibody Type:
    Polyclonal
  • Application:
    ICC, IP, WB
  • Conjugate:
    Unlabeled
  • Description:
  • Formulation:
    In PBS/50% glycerol, pH 7.2
  • Immunogen:
    Full-length recombinant human Beclin 1
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with Beclin 1 on Western blotting, Immunoprecipitation and Immunocytochemistry.
  • Research Area:
    Autophagy
  • Short Description:
  • Size:
    100 μg
  • Species Reactivity:
    Hamster, Human, Mouse, Rat
  • Storage Temperature:
    -20°C
  • Target:
    Beclin 1
Citations
  1. Berliocchi L et al. Autophagy impairment in a mouse model of neuropathic pain. Mol Pain. 7, 83 (2011),
  2. Hamasaki M et al. Autophagosomes form at ER-mitochondria contact sites. Nature 495, 389-93 (2013),
  3. Matsunaga K et al. Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J Cell Biol. 190, 511-21 (2010),
  4. Russo R et al. Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo. Cell Death Dis. 2, e144 (2011)