Parkinson’s Disease

Parkinson’s disease is a neurodegenerative disease that affects movement and coordination. It is the second most common neurodegenerative disease and there is currently no cure1.

Alpha-synuclein

Alpha-synuclein is a protein of unknown function in the brain that constitutes a major component of Lewy bodies. Lewy bodies are protein clumps in nerve cells that are a hallmark of Parkinson’s disease2.

Code No.NameSpecies ReactivitiesApplications
AT-5008 alpha-Synuclein mAb               Human                               WB, ELISA, IHC

DJ-1 (PARK 7)

DJ-1 is a protein with many functions including transcriptional regulation, antioxidative stress reaction, and chaperone, protease, and mitochondrial regulation. Defects in the expression of this protein are thought to cause certain types of Parkinson’s disease3.

Code No.NameSpecies ReactivitiesApplications
M043-3 Anti-DJ-1 (Human) mAb Human WB

Citations

  1. "Parkinson's Disease Overview." National Parkinson Foundation. National Parkinson Foundation, Web.
  2. "Alpha-synuclein and Parkinson's Disease | The Michael J. Fox Foundation."The Michael J. Fox Foundation. The Michael J. Fox Foundation, Web.
  3. Hiroyoshi Ariga, Kazuko Takahashi-Niki, Izumi Kato, Hiroshi Maita, Takeshi Niki, and Sanae M. M. Iguchi-Ariga, “Neuroprotective Function of DJ-1 in Parkinson’s Disease,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 683920, 9 pages.

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