MHC Tetramers- Human and Mouse Class I
T cell receptors (TCRs) expressed on the surface of T cells specifically recognize and bind to complexes of major histocompatibility complex (MHC) molecules and peptide fragments. CD8+ T cells, also called cytotoxic T lymphocytes (CTLs), specifically recognize MHC class I molecules and peptide complexes. CTLs directly kill target cells including virus-infected and cancer cells. MBL International has incorporated α3 domain mutations* in HLA class I tetramers and is the only manufacturer of MHC multimers with this technology to enhance specificity for the antigen-specific T cell receptor. We offer MHC Class I tetramers for many species including human and mouse. If you do not see an item for your research, please contact us for personalized support.
*Only human and macaque HLA Class I Tetramers contain the alpha 3 mutation.