Anti-TERT (Human) mAb

  • Applications
    • ChIP
    • ICC
    • IP
    • WB
  • Target TERT (Human)
  • Host Species Mouse
  • Species Reactivities Human
  • Code # M216-3
  • Size 100 µl
  • Price
    $373.17
Specifications

Alternative Names

TP2, TRT, CMM9, EST2, TCS1, hTRT, DKCA2, DKCB4, PFBMFT1

Background

Human telomerase reverse transcriptase (hTERT) is 1132 amino acids, 127 kDa protein, that is the catalytic subunit of the telomerase. Telomerase is an RNA-dependent DNA polymerase that catalyzes the addition of telomeric repeat unit, 5'-TTAGGG-3', to chromosome ends. Human telomerase consists of three major subunits: TERT, a template RNA called hTR, and telomerase-associated protein (TEP-1). hTERT and hTR are minimally required to reconstitute telomerase activity in vitro. In these subunits, hTR is constitutively expressed; TERT transcription is a primary mechanism for regulation of telomerase activity. In most human somatic cells, telomerase activity is undetectable, whereas approximately 85% of human cancers, including breast, prostate, stomach, bladder, colon, and liver cancer, have telomerase activity. Activation of telomerase is implicated in cell immortalization and cancer cell pathogenesis.
  • Antibody Type:
    Monoclonal
  • Application:
    ChIP, ICC, IP, WB
  • Clone Number:
    10E9-2
  • Conjugate:
    Unlabeled
  • Description:

    Monoclonal Antibody of 100 µl targeting TERT (Human) for WB,IP,ICC,ChIP.

  • Formulation:
    1 mg/mL in PBS/50% glycerol, pH 7.2
  • Gene ID (Human):
  • Host Species:
    Mouse
  • Product Type:
    Antibody
  • Research Area:
    Cancer
  • Short Description:

    TERT (Human) Monoclonal Antibody.

  • Size:
    100 µl
  • Species Reactivity:
    Human
  • Storage Temperature:
    -20°C
  • Target:
    TERT (Human)
Citations
  1. Maida Y et al. Involvement of telomerase reverse transcriptase in heterochromatin maintenance. Mol Cell Biol. 34, 1576-93 (2014)
References
  1. Maida, Y., et al., Mol. Cell Biol. 34, 1576-1593 (2014) [WB, IP, IC, ChIP]