Anti-LC3 (Human) mAb (Monoclonal Antibody)
LC3 Monoclonal Antibody.
Specifications:
Description
Monoclonal Antibody of 100 µl targeting LC3 for WB.
| Target: | LC3 |
|---|---|
| Product Type: | Antibody |
| Size: | 100 µl |
| Application: | WB |
| Research Area / Disease: | Autophagy |
| Conjugate: | Unlabeled |
| Antibody Type: | Monoclonal |
| Clone Number: | 8E10 |
| Concentration: | 1 mg/mL |
| Formulation: | 1 mg/mL in PBS containing 50% Glycerol (pH 7.2). No preservative is contained. |
| Isotype: | IgG2a ĸ |
| Immunogen: | Human LC3 (MAP1LC3B), 1-120 aa (recombinant) |
| Host Species: | Mouse |
| Species Reactivity: | Hamster, Human, Mouse, Rat |
| Source: | Purified IgG from hybridoma supernatant |
| Reactivity: | This clone reacts with LC3B and does not cross-react with LC3A, LC3C, GATE-16 and GABARAP |
| Gene ID Human: | |
| Gene ID Mouse: | |
| Gene ID Rat: | |
| Storage Temperature: | -20°C |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
Citations
- Maejima Y et al. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med. 19, 1478-88 (2013),
- Mukai R, Ohshima T. HTLV-1 HBZ positively regulates the mTOR signaling pathway via inhibition of GADD34 activity in the cytoplasm. Oncogene. (2013) In press.,
- Margariti A et al. XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. J Biol Chem 288, 859-72 (2013)
- Mukai, R., and Ohshima, T., Oncogene (2013) In press.
- Maejima, Y., et al., Nat Med. 19, 1478-1488 (2013) [WB]
- Margariti, A., et al., J Biol Chem. 288, 859-872 (2013) [WB]
- Kozako T et al. Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines. BMC Cancer. 18, 791 (2018)
- Saito T et al. An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia. J Clin Invest. 129, 802-819 (2019)rn
- Slowicka K et al. Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis. Nat Commun. 10, 1834 (2019)
- Forte, M., Bianchi, F., Cotugno, M. et al. An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation. Cell Death Dis 12, 919 (2021).
References
- Jia, W., et al., J. Immunol. 186, 5313-5322 (2011)
- Tabata, K., et al., Mol. Biol. Cell 21, 4162-4172 (2010)
- Mookerjee, S., et al., J. Neurosci. 29, 15134-15144 (2009)
- Saitoh, T., et al., Nature 456, 264-268 (2008)
- Kabeya, Y., et al., J. Cell Sci. 117, 2805-2812 (2004)
- Mizushima, N., et al., Mol. Biol. Cell 15, 1101-1111 (2004)
- Mizushima, N., et al., J. Cell Biol. 152, 657-668 (2001)
- Schmitz, J., et al., Immunity 23, 479-490 (2005)
Related Content:
Brochures
Autophagy-Related Products Catalog
