Anti-IL-18 receptor 1 (Clone 64G4) (Mouse) mAb

  • Applications
    • WB
  • Target IL-18
  • Host Species Rat
  • Species Reactivities Mouse
  • Code # M166-3
  • Size 100 µg
  • Price
    $284.06
Specifications

Alternative Names

interleukin 18 (interferon-γ-inducing factor), IGIF, IL1F4, IL-1g, IL-18

Background

IL-18 is a proinflammatory cytokine that can synergize with IL-12 to increase IFN-γ production, NK cell cytotoxity, and Th1 responses, and involves in chronic inflammation, autoimmune diseases, and a variety of cancers. The receptor of IL-18 is a complex of two polypeptide chains, IL-18 receptor 1 (IL-18R1/IL-18Rα/CD218a) and IL-18 receptor accessory protein (IL-18Rap/IL-18Rβ/CD218b). Both chain are essential for IL-18 signal transduction. IL-18R1 is a glycosylated membrane protein of 60-100 kDa expressed on variety of cells containing Th1 cells, NK cells, renal epithelial cells and prostate cancer cells. It is a member of IL-1 receptor family and works as ligand binding chain of IL-18R complex.
  • Antibody Type:
    Monoclonal
  • Application:
    WB
  • Clone Number:
    64G4
  • Concentration:
    1 mg/mL
  • Conjugate:
    Unlabeled
  • Description:

    Monoclonal Antibody of 100 µg targeting IL-18 for WB.

  • Formulation:
    100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Host Species:
    Rat
  • Immunogen:
    120-140 aa of mouse IL-18R1
  • Isotype:
    IgG2a ĸ
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with mouse IL-18R1 on Western blotting.
  • Research Area:
    Immunology
  • Short Description:

    IL-18 Monoclonal Antibody.

  • Size:
    100 µg
  • Species Reactivity:
    Mouse
  • Storage Temperature:
    -20°C
  • Target:
    IL-18
References
  1. Born, T. L., et al., J. Biol. Chem. 273, 29445-29450 (1998)
  2. Yoshimoto, T., et al., J. Immunol. 161, 3400-3407 (1998)
  3. Torigoe, K., et al., J. Biol. Chem. 272, 25737-25742 (1997)
  4. Parnet, P., et al., J. Biol. Chem. 271, 3967-3970 (1996)