Anti-p62 (SQSTM1) (Human) mAb (Monoclonal Antibody)
p62 Monoclonal Antibody.
Specifications:
Description
Monoclonal Antibody of 100 µl targeting p62 for FCM, ICC, IHC, IP, WB.
| Target: | p62 |
|---|---|
| Product Type: | Antibody |
| Size: | 100 µl |
| Application: | FCM, ICC, IHC, IP, WB |
| Research Area / Disease: | Autophagy |
| Conjugate: | Unlabeled |
| Antibody Type: | Monoclonal |
| Clone Number: | 5F2 |
| Concentration: | 1 mg/mL |
| Formulation: | 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Isotype: | IgG1 ĸ |
| Immunogen: | Recombinant human p62 (120-440 a.a.) |
| Host Species: | Mouse |
| Species Reactivity: | Human |
| Source: | This antibody was purified from hybridoma (clone 5F2) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell P3U1 with C3H mouse lymphocyte immunized with the recombinant human p62 protein corresponding to amin |
| Reactivity: | This antibody reacts with human p62 on Western blotting, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. |
| Gene ID Human: | |
| Gene ID Mouse: | |
| Storage Temperature: | -20°C |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
Citations
- Akaishi R et al. Autophagy in the placenta of women with hypertensive disorders in pregnancy. Placenta 35, 974-80 (2014),
- Fan W et al. Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy 6, 614-21 (2010),
- Guo X et al. Patulin induces pro-survival functions via autophagy inhibition and p62 accumulation. Cell Death Dis. 4, e822 (2013),
- Janda E et al. Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection. Autophagy 11, 1063-80 (2015),
- Matsumoto G et al. Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. Mol Cell. 44, 279-89 (2011),
- Onodera Y et al. NRF2 immunolocalization in human breast cancer patients as a prognostic factor. Endocr Relat Cancer. 21, 241-52 (2014),
- Park JM et al. Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy. Cancer Biol Ther. 14, 100-7 (2013),
- Rovetta F et al. ER signaling regulation drives the switch between autophagy and apoptosis in NRK-52E cells exposed to cisplatin. Exp Cell Res. 318, 238-50 (2012),
- Schmeisser H et al. Type I interferons induce autophagy in certain human cancer cell lines. Autophagy 9, 683-96 (2013),
- Soll C et al. Serotonin promotes tumor growth in human hepatocellular cancer. Hepatology 51, 1244-54 (2010),
- Wang BS et al. Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP. Clin Sci (Lond). 124, 203-14 (2013),
- Zhu X et al. Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. J Clin Invest. 125, 1098-110 (2015)
- Kanda R et al. Expression of the glucagon-like peptide-1 receptor and its role in regulating autophagy in endometrial cancer. BMC Cancer 18, 657 (2018)
- Qiu J et al. Distinct subgroup of the Ras family member 3 (DIRAS3) expression impairs metastasis and induces autophagy of gastric cancer cells in mice. J Cancer Res Clin Oncol. 144, 1869-1886 (2018)
- Mori H et al. Induction of selective autophagy in cells replicating hepatitis C virus genome. J Gen Virol. 99, 1643-1657 (2018)
- Nakashima A et al. Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts. Sci Rep. 9, 11466 (2019)
- Ishii S et al. Identification of a factor controlling lysosomal homeostasis using a novel lysosomal trafficking probe. Sci Rep. 9, 11635 (2019)
References
- Ichimura, Y., et al., J. Biol. Chem. 283, 22847-22857 (2008)
- Komatsu, M., et al., Cell 131, 1149-1163 (2007)
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