Anti-Atg10 (Human) mAb

  • Applications
    • WB
  • Target Atg10
  • Host Species Mouse
  • Species Reactivities Human
  • Code # M151-3
  • Size 100 μg
  • Price
    $324.38
Specifications

Alternative Names

autophagy related 10, APG10, APG10L, pp12616

Background

Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. Autophagy has two ubiquitin-like conjugation systems, the Atg12 and LC3-II systems. In the Atg12 conjugation system, the Atg16L-Atg12-Atg5 forms 800 kDa complex that elongates autophagic isolation membrane. After completion of the formation of the autophagosome, the Atg12-Atg5-Atg16L complex dissociates from the membrane. In recent study, nonsynonymous SNP analysis has indicated that ATG16L1 is a Crohn's disease susceptibility gene.
  • Antibody Type:
    Monoclonal
  • Application:
    WB
  • Clone Number:
    5A7
  • Concentration:
    1 mg/mL
  • Conjugate:
    Unlabeled
  • Description:

    Monoclonal Antibody of 100 μg targeting Atg10 for WB.

  • Formulation:
    100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Host Species:
    Mouse
  • Immunogen:
    Human full-length Atg10 (1-220 a.a.)
  • Isotype:
    IgG1 ĸ
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with human Atg10(26 kDa) on Western blotting.
  • Research Area:
    Autophagy
  • Short Description:

    Atg10 Monoclonal Antibody.

  • Size:
    100 μg
  • Species Reactivity:
    Human
  • Storage Temperature:
    -20°C
  • Target:
    Atg10
Citations
  1. Jiang H et al. Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity. J Virol. 85, 4720-9 (2011),
  2. Jo YK et al. Increased expression of ATG10 in colorectal cancer is associated with lymphovascular invasion and lymph node metastasis. PLoS One 7, e52705 (2012)
References
  1. Nemoto, T., et al., J. Biol. Chem. 278, 39517-39526 (2003)
  2. Kabeya, Y., et al., EMBO J. 19, 5720-5728 (2000)
  3. Mizushima, N., et al., J. Biol. Chem. 273, 33889-33892 (1998)