Anti-Atg16L (Human) mAb (Monoclonal Antibody)

Atg16L Monoclonal Antibody.

Specifications:

Description

Monoclonal Antibody of 100 μg targeting Atg16L for WB.

Target: Atg16L
Product Type: Antibody
Size: 100 μg
Application: WB
Research Area / Disease: Autophagy
Conjugate: Unlabeled
Antibody Type: Monoclonal
Clone Number: 1F12
Concentration: 1 mg/mL
Formulation: 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Isotype: IgG1 ĸ
Immunogen: Recombinant human ATG16L1 TV2 (85-588 a.a.)
Host Species: Mouse
Species Reactivity: Human, Mouse, Rat
Source: This antibody was purified from hybridoma (clone 1F12) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell P3U1 with C3H mouse lymphocyte immunized with the recombinant human ATG16L1 TV2 (85-588 aa).
Reactivity: This antibody reacts with Atg16L on Western blotting.
Gene ID Human:

55054

Gene ID Mouse:

77040

Gene ID Rat:

363278

Storage Temperature: '-20°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Citations

  1. Adolph TE et al. Paneth cells as a site of origin for intestinal inflammation. Nature 503, 272-6 (2013),
  2. Murthy A et al. A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3. Nature 506, 456-62 (2014),
  3. Myeku N et al. Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62. J Biol Chem 286, 22426-40 (2011)
    1. Slowicka K et al. Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis. Nat Commun. 10, 1834 (2019)

    References

    1. Matsushita, M., et al., J. Biol. Chem. 282, 6763-6772 (2007)