Anti-XIAP (MIHA/ILP-a) (Human) mAb (Monoclonal Antibody)
XIAP Monoclonal Antibody.
Specifications:
Description
Monoclonal Antibody of 100 μg targeting XIAP for IHC, WB.
| Target: | XIAP |
|---|---|
| Product Type: | Antibody |
| Size: | 100 μg |
| Application: | IHC, WB |
| Research Area / Disease: | Apoptosis |
| Conjugate: | Unlabeled |
| Antibody Type: | Monoclonal |
| Clone Number: | 2F1 |
| Concentration: | 1 mg/mL |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Isotype: | IgG1 |
| Immunogen: | Full-length recombinant human XIAP protein |
| Host Species: | Mouse |
| Species Reactivity: | Human, Mouse, Rat |
| Reactivity: | This antibody reacts with XIAP onWestern blotting. 2F1 recognizes C-terminal region ofXIAP (352-449 aa) and detects 55 kDa of XIAP on WesternBlot using total cell lysate from human or mouse cell line,for example, Jurkat, Raji, NIH/3T3, etc. |
| Gene ID Human: | |
| Gene ID Mouse: | |
| Storage Temperature: | -20°C |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
Citations
- Cillessen SA, et al., Inhibition of the intrinsic apoptosis pathway downstream of caspase-9 activation causes chemotherapy resistance in diffuse large B-cell lymphoma. Clin Cancer Res. 1, 7012-21. 2007,
- Ferreira CG, et al., Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients. Ann Oncol. 12, 799-805. 2001,
- Ferreira CG, et al., Expression of X-linked inhibitor of apoptosis as a novel prognostic marker in radically resected non-small cell lung cancer patients. Clin Cancer Res.7, 2468-74. 2001,
- Marsden VS, et al., Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death. Blood. 107, 1872-7. 2006,
- Muris JJ, et al., Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas. Blood. 105, 2916-23. 2005,
- Silke J, et al., Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proc Natl Acad Sci U S A. 102, 16182-7. 2005,
- Silke J, et al., Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis. J Biol Chem. 279, 4313-21. 2004,
- Tanaka H, et al., 3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling. J Biol Chem. 280, 40965-73. 2005
- Ishikawa C et al. Mitotic kinase PBK/TOPK as a therapeutic target for adult T‑cell leukemia/lymphoma. Int J Oncol. 53, 801-814 (2018)
- Vince JE et al. The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation. Cell Rep. 25, 2339-2353.e4 (2018)rn
References
- Cillessen, S. A., et al., Clin. Cancer Res. 13, 7012-7021 (2007)
- Marsden, V. S., et al., Blood 107, 1872-1877 (2006)
- Tanaka, H., et al., J. Biol. Chem. 280, 40965-40973 (2005)
- Muris, J.J., et al., Blood 105, 2916-2923 (2005)
- Silke, J., et al., PNAS. 102, 16182-16187 (2005)
- Silke, J., et al., J. Biol. Chem. 279, 4313-4321 (2004)
- Park, S-J., et al., J. Biol. Chem. 279, 51057-51067 (2004)
- Ferreira, C. G., et al., Clin. Cancer Res. 7, 2468-2474 (2001)
- Ferreira, C. G., et al., Ann. Onc. 12, 799-805 (2001)
- Li, J., et al. Endocrinology 139, 1321-1328 (1998)
- Farahani, R., et al. Genomics 42, 514-518 (1997)
- Roy, N., et al., EMBO J. 16, 6914-6925 (1997)
- Deveraux, QL., et al. Nature 388, 300-304 (1997)
- Liston, P., et al. Nature 379, 349-353 (1996)
