Anti-XIAP (MIHA/ILP-a) (Human) mAb (Monoclonal Antibody)

XIAP Monoclonal Antibody.



Monoclonal Antibody of 100 μg targeting XIAP for IHC, WB.

Target: XIAP
Product Type: Antibody
Size: 100 μg
Application: IHC, WB
Research Area / Disease: Apoptosis
Conjugate: Unlabeled
Antibody Type: Monoclonal
Clone Number: 2F1
Concentration: 1 mg/mL
Formulation: 1.0 mg/mL in PBS/50% glycerol, pH 7.2
Isotype: IgG1
Immunogen: Full-length recombinant human XIAP protein
Host Species: Mouse
Species Reactivity: Human, Mouse, Rat
Reactivity: This antibody reacts with XIAP onWestern blotting. 2F1 recognizes C-terminal region ofXIAP (352-449 aa) and detects 55 kDa of XIAP on WesternBlot using total cell lysate from human or mouse cell line,for example, Jurkat, Raji, NIH/3T3, etc.
Gene ID Human:


Gene ID Mouse:


Storage Temperature: -20°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.


  1. Cillessen SA, et al., Inhibition of the intrinsic apoptosis pathway downstream of caspase-9 activation causes chemotherapy resistance in diffuse large B-cell lymphoma. Clin Cancer Res. 1, 7012-21. 2007,
  2. Ferreira CG, et al., Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients. Ann Oncol. 12, 799-805. 2001,
  3. Ferreira CG, et al., Expression of X-linked inhibitor of apoptosis as a novel prognostic marker in radically resected non-small cell lung cancer patients. Clin Cancer Res.7, 2468-74. 2001,
  4. Marsden VS, et al., Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death. Blood. 107, 1872-7. 2006,
  5. Muris JJ, et al., Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas. Blood. 105, 2916-23. 2005,
  6. Silke J, et al., Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proc Natl Acad Sci U S A. 102, 16182-7. 2005,
  7. Silke J, et al., Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis. J Biol Chem. 279, 4313-21. 2004,
  8. Tanaka H, et al., 3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling. J Biol Chem. 280, 40965-73. 2005
    1. Ishikawa C et al. Mitotic kinase PBK/TOPK as a therapeutic target for adult T‑cell leukemia/lymphoma. Int J Oncol. 53, 801-814 (2018)
    2. Vince JE et al. The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation. Cell Rep. 25, 2339-2353.e4 (2018)rn


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    2. Marsden, V. S., et al., Blood 107, 1872-1877 (2006)
    3. Tanaka, H., et al., J. Biol. Chem. 280, 40965-40973 (2005)
    4. Muris, J.J., et al., Blood 105, 2916-2923 (2005)
    5. Silke, J., et al., PNAS. 102, 16182-16187 (2005)
    6. Silke, J., et al., J. Biol. Chem. 279, 4313-4321 (2004)
    7. Park, S-J., et al., J. Biol. Chem. 279, 51057-51067 (2004)
    8. Ferreira, C. G., et al., Clin. Cancer Res. 7, 2468-2474 (2001)
    9. Ferreira, C. G., et al., Ann. Onc. 12, 799-805 (2001)
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    13. Deveraux, QL., et al. Nature 388, 300-304 (1997)
    14. Liston, P., et al. Nature 379, 349-353 (1996)
    Code M044-3
    Product Type Antibody
    Size 100 μg
    Application IHC, WB

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