Anti-Txnip (VDUP1) (Human) mAb (Monoclonal Antibody)

VDUP-1/Txnip Monoclonal Antibody.

Specifications:

Description

Monoclonal Antibody of 100 μg targeting VDUP-1/Txnip for IHC, IPP, WB.

Target: VDUP-1/Txnip
Product Type: Antibody
Size: 100 μg
Application: IHC, IP, WB
Research Area / Disease: Apoptosis
Conjugate: Unlabeled
Antibody Type: Monoclonal
Clone Number: JY2
Concentration: 1 mg/mL
Formulation: 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Isotype: IgG1
Immunogen: Recombinant human Txnip/VDUP1
Host Species: Mouse
Species Reactivity: Human, Mouse, Rat
Source: This antibody was purified from hybridoma (clone JY2) supernatant using protein A agarose. This hybridoma was established by fusion of mouse plasmacytoma cell BIOS/2 with Balb/c mouse splenocyte immunized with human recombinant Txnip/VDUP1.
Reactivity: This antibody reacts with Txnip/VDUP1 (50 kDa) on Western blotting and Immunoprecipitation.
Gene ID Human:

10628

Gene ID Mouse:

56338

Gene ID Rat:

117514

Storage Temperature: '-20°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Citations

  1. Hand LE et al. Induction of the metabolic regulator Txnip in fasting-induced and natural torpor. Endocrinology 154, 2081-91 (2013),
  2. Chen J et al. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. Am J Physiol Endocrinol Metab. 296, E1133-9 (2009),
  3. Chen J et al. Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes 57, 938-44 (2008),
  4. Pang ST et al. Thioredoxin-interacting protein: an oxidative stress-related gene is upregulated by glucose in human prostate carcinoma cells. J Mol Endocrinol. 42, 205-14 (2009),
  5. Patwari P et al. Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins. J Biol Chem. 284, 24996-5003 (2009),
  6. Saxena G et al. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. J Biol Chem. 285, 3997-4005 (2010),
  7. Yoshioka J et al. Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circ Res. 101, 1328-38 (2007)
    1. Panse M et al. Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms. PLoS One. 13, e0198016 (2018)
    2. Danzl K et al.  Early inhibition of endothelial retinoid uptake upon myocardial infarction restores cardiac function and prevents cell, tissue, and animal death. J Mol Cell Cardiol. 126 105-117 (2019)
    3. Gunes A et al. Thioredoxin interacting protein promotes invasion in hepatocellular carcinoma. Oncotarget. 9, 36849-36866 (2018)rnrn
    4. Levring TB et al. Tumor necrosis factor induces rapid down-regulation of TXNIP in human T cells. Sci Rep. 9, 16725 (2019)rn

    References

    1. Saxena, G., et al., J. Biol. Chem. 285, 3997-4005 (2010)
    2. Patwari, P., et al., J. Biol. Chem. 284, 24996-25003 (2009)
    3. Chen, J., et al., Am. J. Physiol. Endocrinol. Metab. 296, E1133-E1139 (2009)
    4. Pang, S-T., et al., J. Mol. Endocrinol. 42, 205-214 (2009)
    5. Chen, J., et al., Diabetes, 57, 938-944 (2008)
    6. Yoshioka, J., et al., Circ. Res., 101, 1328-1338 (2007)
    7. Patwari, P., et al., J. Biol. Chem. 281, 21884-21891 (2006)
    8. Yoshioka, J., et al., Circulation 109, 2581-2586 (2004)
    9. Schulze, P. C., et al., J. Biol. Chem. 279, 30369-30374 (2004)

     

    Code K0205-3
    Product Type Antibody
    Size 100 μg
    Application IHC, IP, WB
    Price
    $345.32
    Qty:

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