Anti-Txnip (VDUP1) (Human) mAb (Monoclonal Antibody)
VDUP-1/Txnip Monoclonal Antibody.
Specifications:
Description
Monoclonal Antibody of 100 μg targeting VDUP-1/Txnip for IHC, IPP, WB.
| Target: | VDUP-1/Txnip |
|---|---|
| Product Type: | Antibody |
| Size: | 100 μg |
| Application: | IHC, IP, WB |
| Research Area / Disease: | Apoptosis |
| Conjugate: | Unlabeled |
| Antibody Type: | Monoclonal |
| Clone Number: | JY2 |
| Concentration: | 1 mg/mL |
| Formulation: | 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Isotype: | IgG1 |
| Immunogen: | Recombinant human Txnip/VDUP1 |
| Host Species: | Mouse |
| Species Reactivity: | Human, Mouse, Rat |
| Source: | This antibody was purified from hybridoma (clone JY2) supernatant using protein A agarose. This hybridoma was established by fusion of mouse plasmacytoma cell BIOS/2 with Balb/c mouse splenocyte immunized with human recombinant Txnip/VDUP1. |
| Reactivity: | This antibody reacts with Txnip/VDUP1 (50 kDa) on Western blotting and Immunoprecipitation. |
| Gene ID Human: | |
| Gene ID Mouse: | |
| Gene ID Rat: | |
| Storage Temperature: | -20°C |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
Citations
- Hand LE et al. Induction of the metabolic regulator Txnip in fasting-induced and natural torpor. Endocrinology 154, 2081-91 (2013),
- Chen J et al. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. Am J Physiol Endocrinol Metab. 296, E1133-9 (2009),
- Chen J et al. Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes 57, 938-44 (2008),
- Pang ST et al. Thioredoxin-interacting protein: an oxidative stress-related gene is upregulated by glucose in human prostate carcinoma cells. J Mol Endocrinol. 42, 205-14 (2009),
- Patwari P et al. Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins. J Biol Chem. 284, 24996-5003 (2009),
- Saxena G et al. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. J Biol Chem. 285, 3997-4005 (2010),
- Yoshioka J et al. Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circ Res. 101, 1328-38 (2007)
- Panse M et al. Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms. PLoS One. 13, e0198016 (2018)
- Danzl K et al. Early inhibition of endothelial retinoid uptake upon myocardial infarction restores cardiac function and prevents cell, tissue, and animal death. J Mol Cell Cardiol. 126 105-117 (2019)
- Gunes A et al. Thioredoxin interacting protein promotes invasion in hepatocellular carcinoma. Oncotarget. 9, 36849-36866 (2018)rnrn
- Levring TB et al. Tumor necrosis factor induces rapid down-regulation of TXNIP in human T cells. Sci Rep. 9, 16725 (2019)rn
References
- Saxena, G., et al., J. Biol. Chem. 285, 3997-4005 (2010)
- Patwari, P., et al., J. Biol. Chem. 284, 24996-25003 (2009)
- Chen, J., et al., Am. J. Physiol. Endocrinol. Metab. 296, E1133-E1139 (2009)
- Pang, S-T., et al., J. Mol. Endocrinol. 42, 205-214 (2009)
- Chen, J., et al., Diabetes, 57, 938-944 (2008)
- Yoshioka, J., et al., Circ. Res., 101, 1328-1338 (2007)
- Patwari, P., et al., J. Biol. Chem. 281, 21884-21891 (2006)
- Yoshioka, J., et al., Circulation 109, 2581-2586 (2004)
- Schulze, P. C., et al., J. Biol. Chem. 279, 30369-30374 (2004)
