Anti-Txnip (VDUP1) (Human) mAb

  • Applications
    • IP
    • WB
  • Target VDUP-1/Txnip
  • Host Species Mouse
  • Species Reactivities Human, Mouse
  • Code # K0204-3
  • Size 100 μg
  • Price
    $328.61
Specifications

Alternative Names

Vitamin D3 up-regulated protein 1, Thioredoxin (TRX)-interacting protein

Background

Vitamin D3 up-regulated protein 1 (VDUP-1), also called Thioredoxin (TRX)-interacting protein, is an endogenous inhibitor of TRX. Redox-dependent regulation of VDUP-1 by mitogenic factors through Reactive oxygen species (ROS) and the specific binding of VDUP-1 to the redox-sensitive cysteine-sulfide center of TRX modulate intracellular levels of ROS and the mitogenic activity of TRX.
  • Antibody Type:
    Monoclonal
  • Application:
    IP, WB
  • Clone Number:
    JY1
  • Concentration:
    1 mg/mL
  • Conjugate:
    Unlabeled
  • Description:

    Monoclonal Antibody of 100 μg targeting VDUP-1/Txnip for IPP, WB.

  • Formulation:
    100 μg IgG in 100 μl PBS containing 50% glycerol, pH 7.2. Contains nopreservatives.
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Gene ID (Rat):
  • Host Species:
    Mouse
  • Immunogen:
    Recombinant human Txnip/VDUP1
  • Isotype:
    IgG2b
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with VDUP-1 (50 kDa) by Western blotting.
  • Research Area:
    Cell Biology
  • Short Description:

    VDUP-1/Txnip Monoclonal Antibody.

  • Size:
    100 μg
  • Species Reactivity:
    Human, Mouse
  • Storage Temperature:
    -20°C
  • Target:
    VDUP-1/Txnip
Citations
  1. Nivet-Antoine Y et al. trans-Resveratrol downregulates Txnip overexpression occurring during liver ischemia-reperfusion. Biochimie. 92, 1766-71 (2010),
  2. Yoshioka J et al. Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circ. Res. 101, 1328-1338 (2007),
  3. Yu Y et al. Overexpression of thioredoxin-binding protein 2 increases oxidation sensitivity and apoptosis in human lens epithelial cells. Free Radic Biol Med. 57, 92-104 (2013)
References
  1. Yu, Y., et al., Free Radic Biol Med. 57, 92-104 (2013)
  2. Nivet-Antoine,V., et al., Biochimie. 92, 1766-1771 (2010)[WB]
  3. Yoshioka, J., et al., Circ. Res. 101, 1328-1338 (2007) [WB]
  4. Jeon, J-H., et al., Cancer Res. 65, 4485-4489 (2005)
  5. Yoshioka, J., et al., Circulation 109, 2581-2586 (2004)
  6. Schulze, P. C., et al., J. Biol. Chem. 279, 30369-30374 (2004)