Active Mouse Caspase-3

  • Applications
    • BL
  • Target caspase-3
  • Code # JM-1183-100
  • Size 100 Units
  • Price
    $425.75
Specifications

Alternative Names

Active Mouse Caspase-3, Caspase-3 Enzyme, caspase-3, mouse caspase-3, mouse caspases, active caspases, caspase-3 assay positive control

Background

Caspase-3 (also know as CPP32, Yama and apopain) is a major member of the caspase-family of cysteine proteases. Caspase-3 exists in cells as an inactive 32 kDa proenzyme. During apoptosis procaspase-3 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases, such as caspase-6 (Mch2), caspase-8 (Flice) and grazyme B. The processed form of caspase-3 consists of large (17 kD) and small (11 kD) subunits which associate to form the active enzyme. The active caspase-3 has been shown involving in the proteolysis of several important molecules, such as poly (ADP-ribose) polymerase (PARP), the sterol regulatory element binding proteins (SREBPs), focal adhesion kinase (FAK), and others. The recombinant active human caspase-3 expressed in E. coli spontaneously undergoes autoprocessing to yield subunits characteristic of the native enzyme.
  • Application:
    BL
  • Description:
    caspase-3 Protein of 100 Units .
  • Product Type:
    Recombinant Protein
  • Research Area:
    Apoptosis
  • Short Description:
    caspase-3 Protein.
  • Size:
    100 Units
  • Storage Temperature:
    -70°C
  • Target:
    caspase-3