Active Human Caspase-3

  • Target Caspase-3
  • Code # JM-1083-25
  • Size 25 Units
  • Price
    $158.13
Specifications

Alternative Names

Active Human Caspase-3, Active Caspase-3, Caspase-3 Enzyme, Recombinant caspase-3, human caspase-3, human caspases, active caspases

Background

Caspase-3 (also know as CPP32, Yama and apopain) is a major member of the caspase-family of cysteine proteases. Caspase-3 exists in cells as an inactive 32 kDa proenzyme. During apoptosis procaspase-3 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases, such as caspase-6 (Mch2), caspase-8 (Flice) and grazyme B. The processed form of caspase-3 consists of large (17 kD) and small (11 kD) subunits which associate to form the active enzyme. The active caspase-3 has been shown involving in the proteolysis of several important molecules, such as poly (ADP-ribose) polymerase (PARP), the sterol regulatory element binding proteins (SREBPs), focal adhesion kinase (FAK), and others. The recombinant active human caspase-3 expressed in E. coli spontaneously undergoes autoprocessing to yield subunits characteristic of the native enzyme (Full length gene Accession No. NP_004337) .
  • Description:
    Caspase-3 Protein of 25 Units.
  • Product Type:
    Recombinant Protein
  • Research Area:
    Apoptosis
  • Short Description:
    Caspase-3 Protein.
  • Size:
    25 Units
  • Storage Temperature:
    -70°C
  • Target:
    Caspase-3