IL-18 (Interleukin-18)

IL-18 is a cytokine produced by dendritic cells, monocytes, macrophages, neutrophils and epithelial cells. It facilitates primarily Th1-type immunoreactions by acting on T cells. Stimulation of Th1 cells with IL-18 in the presence of anti-CD3 antibody triggers production of IL-13 (a Th2 type 2 helper cell cytokine) as well as IFN-γ. Furthermore, action of IL-18 on basophils and mast cells cause complex physiological actions, including allergic reactions. IL-18 binding protein (IL-18BP) is a serum inhibitor of IL-18 activity. Under normal conditions, the abundance of IL-18BP exceeding that of IL-18 suppresses IL-18 activity, whereas up-regulated expression of IL-18 at the onset of an inflammatory reaction seems to intensify the reaction.

In regard to diseases, high levels of IL-18 are detected in the blood of patients with allergic diseases (bronchial asthma, atopic dermatitis, allergic rhinitis) and those with autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus [SLE], adult Still’s disease, multiple sclerosis, Chrohn’s disease, ulcerative colitis). IL-18 is also found in the urine of patients with acute renal disorder and appears to mediate the progression of type 2 diabetes.

Minimal Background in Western Blotting

Anti-Pro-IL18 Antibody
Catalog Number: M156-3

Anti-Pro-IL18 Antibody Western Blot 

Ideal for Flow Cytometry 

Anti-IL18 Receptor 1 Antibody
Catalog Number:  M159-3

Anti-IL18 Receptor 1 Antibody M159-3 FCM

References

  1. Liang D, Ma W, et al., Cell. Mol. Immunol., 3, 303-6 (2006), PMID: 16978540
  2. Washburn KK, Zappitelli M, Nephrol. Dial. Transplant., 23, 566-72 (2008), PMID: 17911094
  3. Troseid M, Seljeflot I, et al., Cardiovasc. Diabetol. 9, 11 (2010), PMID: 20331890

 

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