IL-18 is a cytokine produced by dendritic cells, monocytes, macrophages, neutrophils and epithelial cells. It facilitates primarily Th1-type immunoreactions by acting on T cells. Stimulation of Th1 cells with IL-18 in the presence of anti-CD3 antibody triggers production of IL-13 (a Th2 type 2 helper cell cytokine) as well as IFN-γ. Furthermore, action of IL-18 on basophils and mast cells cause complex physiological actions, including allergic reactions. IL-18 binding protein (IL-18BP) is a serum inhibitor of IL-18 activity. Under normal conditions, the abundance of IL-18BP exceeding that of IL-18 suppresses IL-18 activity, whereas up-regulated expression of IL-18 at the onset of an inflammatory reaction seems to intensify the reaction.
In regard to diseases, high levels of IL-18 are detected in the blood of patients with allergic diseases (bronchial asthma, atopic dermatitis, allergic rhinitis) and those with autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus [SLE], adult Still’s disease, multiple sclerosis, Chrohn’s disease, ulcerative colitis). IL-18 is also found in the urine of patients with acute renal disorder and appears to mediate the progression of type 2 diabetes.
Minimal Background in Western Blotting
Catalog Number: M156-3
Ideal for Flow Cytometry
Anti-IL18 Receptor 1 Antibody
Catalog Number: M159-3
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