Anti-1-methyladenosine (m1A) mAb

  • Applications
    • ELISA
    • ICC
    • IHC
    • IP
  • Target 1-methyladenosine (m1A)
  • Host Species Mouse
  • Code # D345-3
  • Size 100 µl
  • Price
    $310.79
Specifications

Alternative Names

m1Ado

Background

In eukaryote, newly synthesized RNA is chemically modified at specific nucleotide position after transcription. N1-methyladenosine (m1A) is one of major modified nucleosides present in most eukaryotic tRNAs and also found in yeast rRNAs. m1A affects structural stability of tRNA and its binding to polysome in translation. Urinary excretion of modified nucleosides including m1A is known to be increased in the patients with various cancers and AIDS. It is reported that the amount of urinary m1A correlates with m1A level in tissue from same patients with esophageal carcinoma. Moreover, elevated serum levels of m1A are also detected under stress conditions.
  • Antibody Type:
    Monoclonal
  • Application:
    ELISA, ICC, IHC, IP
  • Clone Number:
    AMA-2
  • Conjugate:
    Unlabeled
  • Description:
    Monoclonal antibody of 100 µl targeting 1-methyladenosine m1A for IPP, ICC, IHC, ELISA.
  • Formulation:
    1 mg/mL in PBS/50% glycerol, pH 7.2
  • Host Species:
    Mouse
  • Immunogen:
    KLH-conjugated 1-methyladenosine (KLH-m1A)
  • Product Type:
    Antibody
  • Research Area:
    Cell Biology
  • Short Description:
    1-methyladenosine m1A Monoclonal Antibody.
  • Size:
    100 µl
  • Storage Temperature:
    -20°C
  • Target:
    1-methyladenosine (m1A)
Citations
  1. Mishima E et al. Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides. PLoS One 10, e0143756 (2015)
References
  1. Mishima, E., et al., J. Am. Soc. Nephrol. (2014) In press.
  2. Masuda, M., et al., Cancer 72, 3571-3578 (1993)
  3. Itoh, K., et al., Tohoku J. Exp. Med. 168, 329-331 (1992)
  4. Itoh, K., et al., Jpn. J. Cancer. Res. 79, 1130-1138 (1988)