Anti-CD8 (Mouse) mAb-FITC

  • Applications
    • FCM
  • Target CD8
  • Host Species Rat
  • Species Reactivities Mouse
  • Code # D271-4
  • Size 1mL (100 Tests)
  • Price
    $278.49
Specifications

Background

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two α chains, or a heterodimer composed of one α and one β chain. Both α and β chains share significant homology to immunoglobulin variable light chains. CD8 α chains binds to class-I MHC molecules α3 domains. CD8 identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. This monoclonal antibody KT15 reacts with a non-polymorphic epitope on the mouse CD8 α chain (mouse Ly2.1 and Ly2.2 cells).
  • Antibody Type:
    Monoclonal
  • Application:
    FCM
  • Clone Number:
    KT15
  • Conjugate:
    FITC
  • Description:
    Monoclonal antibody conjugated to FITC of 100 tests targeting CD8 for FCM.
  • Formulation:
    100 tests in 1 mL volume of PBS containing 1% BSA and 0.1% ProClin150 .Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty of water when disposing materials containing azide into drain.
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Host Species:
    Rat
  • Immunogen:
    C6 antigen-specific CTL clone H-Y
  • Isotype:
    IgG2a λ
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with mouse CD8 α antigen on Flow cytometry.
  • Research Area:
    Cell Biology
  • Short Description:
    CD8 Monoclonal Antibody.
  • Size:
    1mL (100 Tests)
  • Species Reactivity:
    Mouse
  • Storage Temperature:
    4°C
  • Target:
    CD8
Citations
  1. Asano J, et al. J. Immunol. 184: 736-745 (2010)
  2. Kayamuro H, et al. J. Virol. 84: 12703-12712 (2010)
  3. Nobuoka D, et al. Cancer Immunol Immunother 62:639–652 (2013)
  4. Cash H, et al. Oncotarget 6: 36400–36417 (2015)
  5. Toyota H, et al. Oncol Rep 33: 292-296 (2015)
  6. Kamimura D, et al. Int Immunol 28: 117-126 (2016, MBL)
References
  1. Whiteland, J. L., et al., J. Histochem. Cytochem. 43, 313-320 (1995)
  2. Tomonari, K., and Lovering, E., Immunogenetics 28, 445-451 (1988)