Anti-CD300a/d (MAIR-I/II) (Mouse) mAb-FITC

  • Applications
    • FCM
  • Target MAIR-1/2
  • Host Species Rat
  • Species Reactivities Mouse
  • Code # D178-4
  • Size 100 μl
  • Price
    $311.90
Specifications

Background

Immune responses are regulated by opposing positive and negative signals triggered by the interaction of activating and inhibitory cell surface receptors with their ligands. Shibuya et al. identified novel paired activated and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunoglobulin-like receptor (MAIR) I and MAIR-II, whose extracellular domains are highly conserved by each other. MAIR-I, expressed on the majority of myeloid cells, including macrophages, granulocytes, mast cells, and dendritic cells, contains the tyrosine-based sorting motif and the immunoreceptor tyrosine-based inhibitory motif-like sequences in the cytoplasmic domains. On the other hand, MAIR-II, expressed on subsets of peritoneal macrophages and B cells, associates with the immunoreceptor tyrosine-based activation motif-bearing adaptor DAP12. MAIR-I is also known as CD300a/ CMRF-35-like Ig-like molecule-8 (CLM-8)/leukocyte mono-Ig-like receptor 1 (LMIR1). MAIR-II is also known as CD300d/LMIR2/CLM-4/dendritic cell-derived Ig-like receptor 1 (DIgR1).
  • Antibody Type:
    Monoclonal
  • Application:
    FCM
  • Clone Number:
    TX10
  • Concentration:
    500 μg/ml
  • Conjugate:
    FITC
  • Description:

    Monoclonal antibody conjugated to FITC of 100 µl targeting MAIR-1/2 for FCM.

  • Formulation:
    50 μg IgG in 100 μl volume of PBS containing 1% BSA and 0.09% NaN3.*Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty ofwater when disposing materials containing azide into drain.
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Host Species:
    Rat
  • Immunogen:
    Ba/F3 cells were transfected with mouse MAIR-I
  • Isotype:
    IgG1
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with mouse CD300a/d antigen on Flow cytometry.
  • Research Area:
    Immunology
  • Short Description:

    MAIR-1/2 Monoclonal Antibody.

  • Size:
    100 μl
  • Species Reactivity:
    Mouse
  • Storage Temperature:
    4°C
  • Target:
    MAIR-1/2
References
  1. Okoshi, Y., et al., Int. Immunol. 17, 65-72 (2005)
  2. Yotsumoto, K., et al., J. Exp. Med. 198, 223-233 (2003)
  3. Nakahashi, C., et al., J. Immunol. 178, 765-770 (2007)