Anti-PIP2 (Phosphatidylinositol-3, 4-diphosphate) mAb

  • Applications
    • DB
  • Target PIP2
  • Host Species Mouse
  • Code # D143-3
  • Size 100 μl
  • Price
    $334.18
Specifications

Background

Phosphoinositide (PI) 3-kinases phosphorylate inositol lipids at the 3' position of the inositol ring to generate the 3-phosphoinositides, including PtdIns(3)P, PtdIns(3,4)P2 and PtdIns(3,4,5)P3. These phosphoinositides function as key second messengers in signal transduction and membrane trafficking. PIP2 is involved in maintaining cytoskeletal attachment, and it directs endocytosis through its ability to anchor several coat proteins to the plasma membrane. PIP2 also plays a role in regulation of ion channels and binding of scaffolding proteins. Receptor-mediated activation of PLC catalyzes hydrolysis of PIP2 to produce IP3 and diacylglycerol, causing the release of intracellular Ca2+ and activation of protein kinase C.
  • Antibody Type:
    Monoclonal
  • Application:
    DB
  • Clone Number:
    8C2
  • Concentration:
    1 mg/mL
  • Conjugate:
    Unlabeled
  • Description:

    Monoclonal antibody of 100 µl targeting PIP2 for Dot Blot.

  • Formulation:
    100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained.
  • Host Species:
    Mouse
  • Immunogen:
    Purified PtdIns (3,4) P2
  • Isotype:
    IgG3
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with PtdIns(3,4) P2, and also faintly reacts with PtdIns(4) P.
  • Research Area:
    Cell Biology
  • Short Description:

    PIP2 Monoclonal Antibody.

  • Size:
    100 μl
  • Storage Temperature:
    -20°C
  • Target:
    PIP2
References
  1. Yokogawa, Y., et al., FEBS Lett. 473, 222-226 (2000)