Anti-CD279 (PD-1) (Human) mAb (Monoclonal Antibody)

  • Applications
    • FCM
    • WB
  • Target PD-1
  • Host Species Mouse
  • Species Reactivities Human
  • Code # D132-3
  • Size 100 μg
  • Price
    $306.33
Specifications

Alternative Names

programmed death-1

Background

​Human PD-1 (programmed death-1)is a 55 KDa member of the immunoglobulin superfamily that is induced in cells undergoing apoptosis. The PD-1 protein contains an immunoreceptor tyrosine-based inhibitory motif and is expressed predominantly on activated T and B lymphocytes. PD-1 plays a key role in peripheral tolerance and autoimmune disease and is thought to be involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses. Two novel members of the B7 family have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and up-regulation on activated antigen-presenting cells.
  • Antibody Type:
    Monoclonal
  • Application:
    FCM, WB
  • Clone Number:
    J110
  • Concentration:
    1 mg/mL
  • Conjugate:
    Unlabeled
  • Description:
    Monoclonal antibody of 100 μg targeting PD-1 for FCM, WB.
  • Formulation:
    1.0 mg/mL in PBS/50% glycerol, pH 7.2
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Host Species:
    Mouse
  • Immunogen:
    Fusion protein of human PD-1-Fc
  • Isotype:
    IgG1
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with human PD-1.
  • Research Area:
    Apoptosis
  • Short Description:
    PD-1 Monoclonal Antibody.
  • Size:
    100 μg
  • Species Reactivity:
    Human
  • Storage Temperature:
    -20°C
  • Target:
    PD-1
References
  1. Bennett, F., et al., J.Immuno. 170, 711-719 (2003)
  2. Iwai, Y., et al., Immunol. Lett. 83, 215-220 (2002)