Anti-CD134 (OX40) (Human) mAb

  • Applications
    • FCM
  • Target OX40/CD134
  • Host Species Rat
  • Species Reactivities Human
  • Code # D125-3
  • Size 100 μl
  • Price
    $278.49
Specifications

Background

​OX40 (CD134/TNFRSF4/ACT35) is a 50 kDa of cell surface glycoprotein. OX40, a member of the tumor necrosis factor (TNF) superfamily, is expressed primarily on activated CD4+​ T cells. OX40 interacts with OX40 ligand antigen (OX40L, also known as CD252/gp34/CD134L) expressed on activated B cells and antigen presenting cells results in enhanced T cell proliferation and induction of IL-2 production. OX40/OX40L interaction provides a costimulatory signal, resulting in enhanced T cell proliferation and cytokine production. Then, cell proliferation and immunoglobulin secretion in activated B cells are enhanced. OX40/OX40L system mediates the adhesion of activated or HTLV-I-transformed T cells to vascular endothelial cells. TRAF2 and TRAF5 binding to OX40 led to NF-ĸ​B activation, and TRAF3 binding appeared to inhibit NF-ĸ​B activation​.
  • Antibody Type:
    Monoclonal
  • Application:
    FCM
  • Clone Number:
    W4-3
  • Concentration:
    1 mg/mL
  • Conjugate:
    Unlabeled
  • Description:
    Monoclonal antibody of 100 µl targeting OX40/CD134 for FCM.
  • Formulation:
    100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained.
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Host Species:
    Rat
  • Immunogen:
    Human OX40 transfectant
  • Isotype:
    IgG2a
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with CD134 antigen on Flow cytometry.
  • Research Area:
    Cell Biology
  • Short Description:
    OX40/CD134 Monoclonal Antibody.
  • Size:
    100 μl
  • Species Reactivity:
    Human
  • Storage Temperature:
    -20°C
  • Target:
    OX40/CD134
References
  1. Kawamata, S., et al., J. Biol. Chem. 273, 5808-5814 (1998)
  2. Latza, U., et al., Europ. J. Immun. 24, 677-683 (1994)