Anti-CD184 (CXCR4) mAb-FITC

  • Applications
    • FCM
  • Target CD184
  • Host Species Rat
  • Species Reactivities Human
  • Code # D123-4
  • Size 100 μl
  • Price
    $272.92
Specifications

Background

CXCR4/CD184/LESTR/fusin/NPY3R is a G protein-coupled receptor for the CXC chemokine SDF-1. Binding of SDF-1 induces CXCR4 phosphorylation by Ser/Thr kinases, leading to CXCR4 internalization via clathrin-coated pits. CXCR4 functions include co-stimulation in pre-B cell proliferation, induction of apoptosis, and HIV entry, since CXCR4 is one of the 2 major HIV/SIV co-receptors. Early infection with HIV-1 is dominated by CCR5-tropic (R5) viruses. The evolution of CXCR4-tropic (X4) viruses occurs later in the infection and is associated with rapid disease progression. CXCR4 mediates chemotaxis in mature and progenitor blood cells and is essential for B lympho- and myelopoiesis, cardiogenesis, blood vessel formation and cerebellar development. Although ubiquitously expressed in blood and tissue cells, its role in blood and tissue homeostasis is not fully understood. CXCR4 is predominantly stored intracellularly, and may contribute to the inefficiency in transmission and propagation of X4-tropic viruses
  • Antibody Type:
    Monoclonal
  • Application:
    FCM
  • Clone Number:
    A145
  • Conjugate:
    FITC
  • Description:
    Monoclonal antibody conjugated to FITC of 100 µl targeting CD184 for FCM.
  • Formulation:
    50 μg IgG in 100 μl volume of PBS containing 1% BSA and 0.09% NaN3.Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty of water when disposing materials containing azide into drain.
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Host Species:
    Rat
  • Immunogen:
    Cos-1 cells were introduced CXCR4
  • Isotype:
    IgG1
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with CD184 antigen on Flow cytometry. This clone A145 recognizes N-terminus extracellular domain of CXCR4.
  • Research Area:
    Immunology
  • Short Description:
    CD184 Monoclonal Antibody.
  • Size:
    100 μl
  • Species Reactivity:
    Human
  • Storage Temperature:
    4°C
  • Target:
    CD184
Citations
  1. Cesano A et al. Functional pathway analysis in acute myeloid leukemia using single cell network profiling assay: effect of specimen source (bone marrow or peripheral blood) on assay readouts.Cytometry B Clin Cytom. 82, 158-72
    (2012)
References
  1. Nimura, F., et al., Experimental Biology and Medicine 231, 431-443 (2006)
  2. Navenot, J-M., et al., Cancer Res. 65, 10450-10456 (2005)
  3. Ichiyama, K., et al., PNAS 100, 4185-4190 (2003)
  4. Tanaka, R., et al., J. Virol. 75, 11534-11543 (2001)