Anti-CD274 (PD-L1) (Human) mAb-Biotin

  • Applications
    • FCM
  • Target CD274
  • Host Species Mouse
  • Species Reactivities Human
  • Code # D092-6
  • Size 1 mL
  • Price
    $306.33
Specifications

Background

Programmed death ligand 1 (PD-L1, also known as CD274/B7-H1), a member of B7 family was identified by searching for molecules that share homology with the immunoglobulin V and C domains of B7-1 and B7-2 among the human cDNA expressed sequence tags in the National Center for Biotechnology Information database. PD-L1 is a ligand for programmed death 1 (PD-1) which belongs to the CD28/CTLA4 subfamily. Although in vitro study indicated that the cross-linking of PD-1 by PD-L1 leads to down-regulation of T-cell responses, some studies have shown that T cells stimulated with low levels of anti-CD3 and immobilized PD-L1-Ig were activated, proliferation and production of IFN- GM-CSF and IL-10 from the T cells were enhanced.
  • Antibody Type:
    Monoclonal
  • Application:
    FCM
  • Clone Number:
    MIH3
  • Concentration:
    20 μg/ml
  • Conjugate:
    Biotin
  • Description:
    Monoclonal antibody conjugated to biotin of 1mL targeting CD274 for FCM
  • Formulation:
    20 ug/mL in PBS/1% BSA/0.09% sodium azide
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Host Species:
    Mouse
  • Immunogen:
    L cells were transfected with full-length human PD-L1
  • Isotype:
    IgG1
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with CD274 antigen on Flow cytometry.
  • Research Area:
    Apoptosis
  • Short Description:
    CD274 Monoclonal Antibody.
  • Size:
    1 mL
  • Species Reactivity:
    Human
  • Storage Temperature:
    4°C
  • Target:
    CD274
References
  1. del Rio, M-L., et al., J. Immunol. 178, 6861-6866 (2007)
  2. Yamazaki, T., et al., J. Immunol. 169, 5538-5545 (2002)
  3. Tamura, H., et al., Blood 97, 1809-1816 (2001)
  4. Dong, H., et al., Nat. Med. 12, 1365-1369 (1999)