Anti-CD274 (PD-L1) (Human) mAb (Functional Grade)

  • Applications
    • FCM
  • Target CD274
  • Host Species Rat
  • Species Reactivities Human
  • Code # D092-3M2
  • Size 100 µl
  • Price
    $306.33
Specifications

Background

Programmed death ligand 1 (PD-L1, also known as CD274/B7-H1), a member of B7 family was identified by searching for molecules that share homology with the immunogloblin V and C domains of B7-1 and B7-2 among the human cDNA expressed sequence tags in the National Center for Biotechnology Information database. PD-L1 is a ligand for programmed death 1 (PD-1) which belongs to the CD28/CTLA4 subfamily. Although in vitro study indicated that the cross-linking of PD-1 by PD-L1 leads to down-regulation of T-cell responses, some studies have shown that T cells stimulated with low levels of anti-CD3 and immobilized PD-L1-Ig were activated, proliferation and production of IFN-g GM-CSF and IL-10 from the T cells were enhanced. The role of PD-L1 is now debatable.
  • Antibody Type:
    Monoclonal
  • Application:
    FCM
  • Clone Number:
    KT15
  • Conjugate:
    Unlabeled
  • Formulation:
    PBS. Azide free, 0.22 µm sterile-filtered Endotoxin level is < 0.5 EU/mg antibody, as determined by the LAL assay
  • Gene ID (Mouse):
  • Host Species:
    Rat
  • Immunogen:
    L cells transfected with full-length human PD-L1 protein
  • Isotype:
    IgG2a λ
  • Product Type:
    Antibody
  • Research Area:
    Immunology
  • Size:
    100 µl
  • Species Reactivity:
    Human
  • Storage Temperature:
    -20°C
  • Target:
    CD274
References
  • Haile, S. T., et al., Cancer Immunol. Res. 2, 610 – 615 (2014)
  • Butte, M. J., et al., Mol. Immunol. 45, 3567-3572 (2008)
  • del Rio, M. L., et al., J. Immunol. 178, 6861-6866 (2007)