Anti-ASC (TMS1) (Human) mAb (Monoclonal Antibody)

ASC Monoclonal Antibody.



Monoclonal antibody of 100 µL targeting ASC for ICC, IHC, IPP, WB.

Target: ASC
Product Type: Antibody
Size: 100 µl
Application: ICC, IHC, IP, WB
Research Area / Disease: Apoptosis
Conjugate: Unlabeled
Antibody Type: Monoclonal
Clone Number: 23-4
Formulation: 100 μg IgG in a 100 μl volume of PBS containing 50% glycerol, pH 7.2. Contains nopreservatices.
Isotype: IgG1
Immunogen: TritonX-100 insoluble fraction of HL-60 cells were treated with retinoic acid
Host Species: Mouse
Species Reactivity: Human
Source: This antibody was purified from hybridoma (clone 23-4) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell P3-X63-AG8.653 with Balb/c mouse splenocyte immunized with Triton X-100 insoluble fraction of retinoic acid-treated HL-60 cells.
Reactivity: This antibody reacts with human ASC (22 kDa) on Western blotting and Immunoprecipitation.
Gene ID Human:


Storage Temperature: -20°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.


  1. Bryan NB et al. Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes. J Inflamm (Lond). 7, 23 (2010),
  2. Masumoto J et al. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J Biol Chem. 274, 33835-8 (1999),
  3. Masumoto J et al. Expression of apoptosis-associated speck-like protein containing a caspase recruitment domain, a pyrin N-terminal homology domain-containing protein, in normal human tissues. J Histochem Cytochem. 49, 1269-75 (2001),
  4. Masumoto J et al. Murine ortholog of ASC, a CARD-containing protein, self-associates and exhibits restricted distribution in developing mouse embryos. Exp Cell Res. 262, 128-33 (2001),
  5. Masumoto J et al. Pyrin N-terminal homology domain- and caspase recruitment domain-dependent oligomerization of ASC. Biochem Biophys Res Commun. 280, 652-5 (2001),
  6. Mayor A et al. A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. Nat Immunol. 8, 497-503. (2007),
  7. Terasawa K et al. Epigenetic inactivation of TMS1/ASC in ovarian cancer. Clin Cancer Res. 10, 2000-6 (2004)


  1. Bryan, N. B., et al., J. Inflamm. (Lond.) 7, 23 (2010)
  2. Mayor, A., et al., Nat. Immunol. 8, 497-503 (2007)
  3. Hasegawa, M., et al., J. Biol. Chem. 280, 15122-15130 (2005)
  4. Terasawa, K., et al., Clin. Cancer Res. 10, 2000-2006 (2004)
  5. Wang, Y., et al., Int. Immunol. 16, 777-786 (2004)
  6. Stehlik, C., et al., J. Immunol. 171, 6154-6163 (2003)
  7. Stehlik, C., et al., J. Exp. Med. 196, 1605-1615 (2002)
  8. Masumoto, J., et al., J. Histochem. Cytochem. 49, 1269-1275 (2001)
  9. Masumoto, J., et al., Exp. Cell Res. 262, 128-133 (2001)
  10. Masumoto, J., et al., Biochem. Biophys. Res. Commun. 280, 652-655 (2001)
  11. Masumoto, J., et al., J. Biol. Chem. 274, 33835-33838 (1999)
Code D086-3
Product Type Antibody
Size 100 µl
Application ICC, IHC, IP, WB

Related Content: