Anti-IL-18 (Mouse) mAb-Biotin

  • Applications
    • ELISA
  • Target IL-18
  • Host Species Rat
  • Species Reactivities Mouse
  • Code # D048-6
  • Size 50 µl
  • Price
    $306.33
Specifications

Alternative Names

interleukin 18 (interferon-γ-inducing factor)

Background

Interleukin 18 (IL - 18) is a n 18 kDa cytokine which identified as a c ostimulatory factor for production of interferon - γ (IFN - γ ) in response to toxic shock and shares functional similarities with IL - 12. IL - 18 is synthesized as a precursor 24 kDa molecule without a signal peptide and must be cleaved to produce an active molec ule. IL - 1 converting enzyme (ICE, Caspase - 1) cleaves pro - IL - 18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL - 18 is produced from Kupffer cells, activated macroph ages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN - γ is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN - γ activates macrophages, enhances NK activity and B cell maturation, proliferation and Ig secretion, induces MHC class I and II antigens, and inhibits osteoclast activation. IL - 18 acts on T helper type - 1 (Th1) T cells and in combination with IL - 12 strongly induces them to produce IFN - γ . Pleiotropic effects of IL - 18 has also been reported, such as, enhancement production of IFN - γ and GM - CSF in p eripheral blood mononuclear cells, production of Th1 cytokines, IL - 2, GM - CSF and IFN - γ in T cells, enhancement of Fas ligand expression by Th1 cells.
  • Antibody Type:
    Monoclonal
  • Application:
    ELISA
  • Clone Number:
    93-10C
  • Conjugate:
    Biotin
  • Description:
    Monoclonal antibody of 50 µl targeting IL-18 for ELISA.
  • Formulation:
    In 50 µl volume of PBS containing1% BSA, 10% glycerol and 0.09%sodiumazide, pH 7.2.*Azide may react with copper or lead in plumbing system to form explosive metalazides.Therefore, always flush plenty ofwater when disposing materials containing a
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Host Species:
    Rat
  • Immunogen:
    Recombinant mouse IL-18
  • Isotype:
    IgG1
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with mouse IL-18on ELISA.
  • Research Area:
    Immunology
  • Short Description:
    IL-18 Monoclonal Antibody.
  • Size:
    50 µl
  • Species Reactivity:
    Mouse
  • Storage Temperature:
    4°C
  • Target:
    IL-18
References
  1. Dao, T., et al., Cell Immunol. 173, 230-235 (1996)
  2. Micallef, M., et al., Eur. J. Immunol. 26, 1647-1651 (1996)
  3. Ushio, S., et al., J. Immunol. 156, 4274-4279 (1996)
  4. Okamura, H., et al., Nature 378, 88-91 (1995)