Anti-IL-18 (Clone 93-10C) (Mouse) mAb (Monoclonal Antibody)
Interleukin 18 (IL-18) is an 18 kDa cytokine which identified as a costimulatory factor for production of interferon-γ (IFN-γ) in response to toxic shock and shares functional similarities with IL-12.
Specifications:
Description
Interleukin 18 (IL-18) is an 18 kDa cytokine which identified as a costimulatory factor for production of interferon-γ (IFN-γ) in response to toxic shock and shares functional similarities with IL-12.
| Target: | IL-18 |
|---|---|
| Product Type: | Antibody |
| Size: | 100 µl |
| Application: | IP, NT |
| Research Area / Disease: | Immunology |
| Conjugate: | Unlabeled |
| Antibody Type: | Monoclonal |
| Clone Number: | 93-10C |
| Concentration: | 1 mg/mL |
| Formulation: | 100 μg IgG in 100 μL volume of PBS containing 50% glycerol. No preservative is contained. |
| Isotype: | IgG1 |
| Immunogen: | Recombinant mouse IL-18 |
| Host Species: | Rat |
| Species Reactivity: | Mouse |
| Source: | This antibody was purified from hybridoma (clone 93-10C) supernatant using protein G agarose. This hybridoma was established by fusion of mouse myeloma cell SP2/0 with SD rat splenocyte immunized with recombinant mouse IL-18. |
| Reactivity: | This antibody reacts with mouse IL-18 on Immunoprecipitation. |
| Gene ID Human: | |
| Gene ID Mouse: | |
| Storage Temperature: | -20°C |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
Citations
- Beadling C, Slifka MK. Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines. Blood 105, 1179-86 (2005),
- Chaix J et al. Cutting edge: Priming of NK cells by IL-18. J Immunol. 181, 1627-31 (2008),
- Fukao T et al. Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells. 164, 64-71 (2000),
- Humann J, Lenz LL. Activation of naive NK cells in response to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells. J Immunol. 184, 5172-8 (2010),
- Kahlenberg JM et al. Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages. J Immunol. 190, 1217-26 (2013),
- Malmgaard L, Paludan SR. Interferon (IFN)-alpha/beta, interleukin (IL)-12 and IL-18 coordinately induce production of IFN-gamma during infection with herpes simplex virus type 2. J Gen Virol. 84, 2497-500 (2003),
- Matsunaga H et al. Physiological stress exacerbates murine colitis by enhancing proinflammatory cytokine expression that is dependent on IL-18. Am J Physiol Gastrointest Liver Physiol. 301, G555-64 (2011),
- Wang SZ et al. IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection. J Immunol. 173, 4040-9 (2004)
- Kahlenberg JM, Carmona-rivera C, Smith CK, Kaplan MJ. Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages. J Immunol. 2013;190(3):1217-26.
- Matsunaga H, Hokari R, Ueda T, et al. Physiological stress exacerbates murine colitis by enhancing proinflammatory cytokine expression that is dependent on IL-18. Am J Physiol Gastrointest Liver Physiol. 2011;301(3):G555-64.
- Humann J, Lenz LL. Activation of naive NK cells in response to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells. J Immunol. 2010;184(9):5172-8.
- Chaix J, Tessmer MS, Hoebe K, et al. Cutting edge: Priming of NK cells by IL-18. J Immunol. 2008;181(3):1627-31.
- Beadling C, Slifka MK. Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines. Blood. 2005;105(3):1179-86.
- Wang SZ, Bao YX, Rosenberger CL, Tesfaigzi Y, Stark JM, Harrod KS. IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection. J Immunol. 2004;173(6):4040-9.
- Min CK, Maeda Y, Lowler K, et al. Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T-cell subsets after experimental allogeneic bone marrow transplantation. Blood. 2004;104(10):3393-9.
- Malmgaard L, Paludan SR. Interferon (IFN)-alpha/beta, interleukin (IL)-12 and IL-18 coordinately induce production of IFN-gamma during infection with herpes simplex virus type 2. J Gen Virol. 2003;84(Pt 9):2497-500.
- Fukao T, Matsuda S, Koyasu S. Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells. J Immunol. 2000;164(1):64-71.
References
- Dao, T., et al., Cell Immunol. 173, 230-235 (1996)
- Micallef, M., et al., Eur. J. Immunol. 26, 1647-1651 (1996)
- Ushio, S., et al., J. Immunol. 156, 4274-4279 (1996)
- Okamura, H., et al., Nature 378, 88-91 (1995)
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