Anti-IL-18 (Clone 93-10C) (Mouse) mAb (Monoclonal Antibody)

Interleukin 18 (IL-18) is an 18 kDa cytokine which identified as a costimulatory factor for production of interferon-γ (IFN-γ) in response to toxic shock and shares functional similarities with IL-12.

Specifications:

Description

Interleukin 18 (IL-18) is an 18 kDa cytokine which identified as a costimulatory factor for production of interferon-γ (IFN-γ) in response to toxic shock and shares functional similarities with IL-12.

Target: IL-18
Product Type: Antibody
Size: 100 µl
Application: IP, NT
Research Area / Disease: Immunology
Conjugate: Unlabeled
Antibody Type: Monoclonal
Clone Number: 93-10C
Concentration: 1 mg/mL
Formulation: 100 µg IgG in 100 µl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Isotype: IgG1
Immunogen: Recombinant mouse IL-18
Host Species: Rat
Species Reactivity: Mouse
Source: This antibody was purified from mouse ascitesfluid using proteinA agarose. This hybridoma wasestablished by fusion of mouse myeloma cell SP2/0 withBalb/c mouse splenocyte immunized with recombinanthuman IL-18.
Reactivity: This antibody reactswith mouse IL-18on Immunoprecipitation.
Gene ID Human:

3606

Gene ID Mouse:

16173

Storage Temperature: -20°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Citations

  1. Beadling C, Slifka MK. Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines. Blood 105, 1179-86 (2005),
  2. Chaix J et al. Cutting edge: Priming of NK cells by IL-18. J Immunol. 181, 1627-31 (2008),
  3. Fukao T et al. Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells. 164, 64-71 (2000),
  4. Humann J, Lenz LL. Activation of naive NK cells in response to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells. J Immunol. 184, 5172-8 (2010),
  5. Kahlenberg JM et al. Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages. J Immunol. 190, 1217-26 (2013),
  6. Malmgaard L, Paludan SR. Interferon (IFN)-alpha/beta, interleukin (IL)-12 and IL-18 coordinately induce production of IFN-gamma during infection with herpes simplex virus type 2. J Gen Virol. 84, 2497-500 (2003),
  7. Matsunaga H et al. Physiological stress exacerbates murine colitis by enhancing proinflammatory cytokine expression that is dependent on IL-18. Am J Physiol Gastrointest Liver Physiol. 301, G555-64 (2011),
  8. Wang SZ et al. IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection. J Immunol. 173, 4040-9 (2004)
  9. Kahlenberg JM, Carmona-rivera C, Smith CK, Kaplan MJ. Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages. J Immunol. 2013;190(3):1217-26.
  10. Matsunaga H, Hokari R, Ueda T, et al. Physiological stress exacerbates murine colitis by enhancing proinflammatory cytokine expression that is dependent on IL-18. Am J Physiol Gastrointest Liver Physiol. 2011;301(3):G555-64.
  11. Humann J, Lenz LL. Activation of naive NK cells in response to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells. J Immunol. 2010;184(9):5172-8.
  12. Chaix J, Tessmer MS, Hoebe K, et al. Cutting edge: Priming of NK cells by IL-18. J Immunol. 2008;181(3):1627-31.
  13. Beadling C, Slifka MK. Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines. Blood. 2005;105(3):1179-86.
  14. Wang SZ, Bao YX, Rosenberger CL, Tesfaigzi Y, Stark JM, Harrod KS. IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection. J Immunol. 2004;173(6):4040-9.
  15. Min CK, Maeda Y, Lowler K, et al. Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T-cell subsets after experimental allogeneic bone marrow transplantation. Blood. 2004;104(10):3393-9.
  16. Malmgaard L, Paludan SR. Interferon (IFN)-alpha/beta, interleukin (IL)-12 and IL-18 coordinately induce production of IFN-gamma during infection with herpes simplex virus type 2. J Gen Virol. 2003;84(Pt 9):2497-500.
  17. Fukao T, Matsuda S, Koyasu S. Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells. J Immunol. 2000;164(1):64-71.

References

  1. Dao, T., et al., Cell Immunol. 173, 230-235 (1996)
  2. Micallef, M., et al., Eur. J. Immunol. 26, 1647-1651 (1996)
  3. Ushio, S., et al., J. Immunol. 156, 4274-4279 (1996)
  4. Okamura, H., et al., Nature 378, 88-91 (1995)
Code D048-3
Product Type Antibody
Size 100 µl
Application IP, NT
Price
$328.61
Qty: