Anti-IL-18 (Clone 39-3F) (Mouse) mAb (Monoclonal Antibody)

IL-18 Monoclonal Antibody.

Specifications:

Description

Monoclonal antibody of 100 µl targeting IL-18 for WB, NT.

Target: IL-18
Product Type: Antibody
Size: 100 µl
Application: NT, WB
Research Area / Disease: Immunology
Conjugate: Unlabeled
Antibody Type: Monoclonal
Clone Number: 39-3F
Concentration: 1 mg/mL
Formulation: 100 µg IgG in 100 µl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Isotype: IgG2a
Immunogen: Recombinant mouse IL-18
Host Species: Rat
Species Reactivity: Mouse
Source: This antibody was purified from mouse ascitesfluid using proteinA agarose. This hybridoma wasestablished by fusion of mouse myeloma cell SP2/0 withBalb/c mouse splenocyte immunized with recombinanthuman IL-18.
Reactivity: This antibody reacts with mouse IL-18on Western blotting.
Gene ID Human:

3606

Gene ID Mouse:

16173

Storage Temperature: -20°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Citations

  1. Hoshino T et al. Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am J Respir Crit Care Med. 176, 49-62 (2007),
  2. Hoshino T et al. Cutting edge: IL-18-transgenic mice: in vivo evidence of a broad role for IL-18 in modulating immune function. J Immunol. 166, 7014-8 (2001),
  3. Lertmemongkolchai G et al. Bystander activation of CD8+ T cells contributes to the rapid production of IFN-gamma in response to bacterial pathogens. J. Immunol. 166, 1097-105 (2001),
  4. Seino H et al. IL-18 mediates the formation of stress-induced, histamine-dependent gastric lesions. Am J Physiol Gastrointest Liver Physiol. 292, G262-7 (2007),
  5. Venkatachalam K et al. Neutralization of interleukin-18 ameliorates ischemia/reperfusion-induced myocardial injury. J Biol Chem. 284,
    7853-65 (2009) 
  6. Venkatachalam, K., et al., J. Biol. Chem. 284, 7853-7865 (2009) [WB]
  7. Hoshino, T., et al., Am. J. Respir. Crit. Care Med. 176 49-62 (2007) [WB]
  8. Seino, H., et al., Am. J. Physiol. Gastrointest. Liver Physiol. 292, G262-G267 (2007) [WB]
  9. Hoshino, T., et al., J. Immunol. 166, 7014-7018 (2001) [WB]
  10. Lertmemongkolchai, G., et al., J. Immunol. 166, 1097-1105 (2001) [Neutralization]
  11. Hoshino T, Kato S, Oka N, et al. Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am J Respir Crit Care Med. 2007;176(1):49-62.
  12. Fujiwara H et al. Microbial metabolite sensor GPR43 controls severity of experimental GVHD. Nat Commun. 9, 3674 (2018)
  13. Yamanishi K et al. Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia. J Transl Med. 16, 314 (2018)

    References

    1. Dao, T., et al. Cell Immunol. 173, 230-235 (1996)
    2. Ushio, S., et al. J. Immunol. 156, 4274-4279 (1996)
    3. Micallef, M., et al. Eur. J. Immunol. 26, 1647-1651 (1996)
    4. Okamura, H., et al. Nature 378, 88-91 (1995)
    Code D046-3
    Product Type Antibody
    Size 100 µl
    Application NT, WB
    Price
    $306.33
    Qty: