Anti-IL-18 (Clone 39-3F) (Mouse) mAb (Monoclonal Antibody)
IL-18 Monoclonal Antibody.
Specifications:
Description
Monoclonal antibody of 100 µl targeting IL-18 for WB, NT.
| Target: | IL-18 |
|---|---|
| Product Type: | Antibody |
| Size: | 100 µl |
| Application: | NT, WB |
| Research Area / Disease: | Immunology |
| Conjugate: | Unlabeled |
| Antibody Type: | Monoclonal |
| Clone Number: | 39-3F |
| Concentration: | 1 mg/mL |
| Formulation: | 100 µg IgG in 100 µl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Isotype: | IgG2a |
| Immunogen: | Recombinant mouse IL-18 |
| Host Species: | Rat |
| Species Reactivity: | Mouse |
| Source: | This antibody was purified from mouse ascitesfluid using proteinA agarose. This hybridoma wasestablished by fusion of mouse myeloma cell SP2/0 withBalb/c mouse splenocyte immunized with recombinanthuman IL-18. |
| Reactivity: | This antibody reacts with mouse IL-18on Western blotting. |
| Gene ID Human: | |
| Gene ID Mouse: | |
| Storage Temperature: | -20°C |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
Citations
- Hoshino T et al. Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am J Respir Crit Care Med. 176, 49-62 (2007),
- Hoshino T et al. Cutting edge: IL-18-transgenic mice: in vivo evidence of a broad role for IL-18 in modulating immune function. J Immunol. 166, 7014-8 (2001),
- Lertmemongkolchai G et al. Bystander activation of CD8+ T cells contributes to the rapid production of IFN-gamma in response to bacterial pathogens. J. Immunol. 166, 1097-105 (2001),
- Seino H et al. IL-18 mediates the formation of stress-induced, histamine-dependent gastric lesions. Am J Physiol Gastrointest Liver Physiol. 292, G262-7 (2007),
- Venkatachalam K et al. Neutralization of interleukin-18 ameliorates ischemia/reperfusion-induced myocardial injury. J Biol Chem. 284,
7853-65 (2009) - Venkatachalam, K., et al., J. Biol. Chem. 284, 7853-7865 (2009) [WB]
- Hoshino, T., et al., Am. J. Respir. Crit. Care Med. 176 49-62 (2007) [WB]
- Seino, H., et al., Am. J. Physiol. Gastrointest. Liver Physiol. 292, G262-G267 (2007) [WB]
- Hoshino, T., et al., J. Immunol. 166, 7014-7018 (2001) [WB]
- Lertmemongkolchai, G., et al., J. Immunol. 166, 1097-1105 (2001) [Neutralization]
- Hoshino T, Kato S, Oka N, et al. Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am J Respir Crit Care Med. 2007;176(1):49-62.
- Fujiwara H et al. Microbial metabolite sensor GPR43 controls severity of experimental GVHD. Nat Commun. 9, 3674 (2018)
- Yamanishi K et al. Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia. J Transl Med. 16, 314 (2018)
References
- Dao, T., et al. Cell Immunol. 173, 230-235 (1996)
- Ushio, S., et al. J. Immunol. 156, 4274-4279 (1996)
- Micallef, M., et al. Eur. J. Immunol. 26, 1647-1651 (1996)
- Okamura, H., et al. Nature 378, 88-91 (1995)
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Pathway Posters
Rho Family Pathway
